Avaliação morfofuncional de testículo humano de pacientes submetidos a tratamentos para o câncer de próstata

Abstract

Histomorphometric studies developed by our group indicate that hormones and irradiation for prostate cancer treatment result in damage effects in men spermatogenic process as significant changes of the testicular parameters. Following the studies, we increase the number of the patients and analyzed with more details some morphometric parameters of the spermatogenesis as the spermatogonial proliferation trying to confirm more precisely the indirect effects of the prostatectomy as the hormonal and the radiotherapy treatments for the prostate cancer to the testicle. The obtained data confirm that the hormonal and radiotherapy treatments for advanced prostate cancer indirectly result the prejudice of the spermatogenic process. The morphological e morphometric analysis indicate that the group of patients that have not received any type of prostate cancer treatment kept a preserved spermatogenesis according to their age range, as the previous prostatectomy to the orchiectomy apparently did not resulted deleterious effect in the spermatogenesis. The group of patients treated with hormone therapy had a blocked spermatogenesis as a rare spermatozoa production. The group of patients treated with radiotherapy treatment were the ones that presented more damages in the testicular parenchyma prevailing seminiferous tubules without germ cells and the presence of Sertoli cells only. The serial concentration of FSH was increased significantly in the group of patients treated with radiation possible due to the action on Sertoli cells functioning. It was verified after the hormone therapy, a small reduction in the spermatogonial proliferation indicating that the spermatogenesis can eventually recover after the treatment ceasing. On the other hand, for the radiotherapy, the deleterious effect was significant on the spermatogonial proliferation showing that, according to the spermatogonia presence, rare of them were in cellular division.