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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/63531
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Campo DCValorIdioma
dc.creatorLuan César da Silvapt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorOslei Paes de Almeidapt_BR
dc.creatorBruno Augusto Linhares de Almeida Marizpt_BR
dc.creatorMárcio Ajudarte Lopespt_BR
dc.creatorRaghu Radhakrishnanpt_BR
dc.creatorMohit Sharmapt_BR
dc.creatorLuiz Paulo Kowalskipt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.date.accessioned2024-01-30T17:48:09Z-
dc.date.available2024-01-30T17:48:09Z-
dc.date.issued2019-12-24-
dc.citation.issue1pt_BR
dc.citation.spagee49pt_BR
dc.citation.epagee55pt_BR
dc.identifier.doihttps://doi.org/10.4317%2Fmedoral.23177pt_BR
dc.identifier.issn16986946pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/63531-
dc.description.resumoBackground: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). Material and methods: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. Results: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. Conclusion: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMedicina oral patología oral y cirugía bucalpt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherNeoplasmspt_BR
dc.subject.otherOral submucous fibrosispt_BR
dc.subject.otherCarcinoma, squamous cellpt_BR
dc.subject.otherImmunitypt_BR
dc.subject.otherDendritic cellspt_BR
dc.subject.otherLeukoplakia, oralpt_BR
dc.subject.otherLangerhans cellspt_BR
dc.subject.otherAntigenspt_BR
dc.titleCD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982989/pt_BR
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