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  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/63545
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Campo DCValorIdioma
dc.creatorPaula Maria Quaglio Bellozipt_BR
dc.creatorGiovanni Freitas Gomespt_BR
dc.creatorMaria Carolina Machado da Silvapt_BR
dc.creatorIsabel Vieira de Assis Limapt_BR
dc.creatorCarla Ribeiro Álvares Batistapt_BR
dc.creatorWellerson de Oliveira Carneiro Juniorpt_BR
dc.creatorJuliana Guimarães Dóriapt_BR
dc.creatorÉrica Leandro Marciano Vieirapt_BR
dc.creatorRafael Pinto Vieirapt_BR
dc.creatorRossimiriam Pereira de Freitaspt_BR
dc.creatorCláudia Natália Ferreirapt_BR
dc.creatorEduardo Candelario-Jalilpt_BR
dc.creatorTony Wyss-Coraypt_BR
dc.creatorFabíola Mara Ribeiropt_BR
dc.creatorAntônio Carlos Pinheiro de Oliveirapt_BR
dc.date.accessioned2024-01-31T14:11:01Z-
dc.date.available2024-01-31T14:11:01Z-
dc.date.issued2019-
dc.citation.volume160pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.neuropharm.2019.107785pt_BR
dc.identifier.issn0028-3908pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/63545-
dc.description.resumoAlzheimer's Disease (AD) is the most prevalent neurodegenerative disorder. Despite advances in the understanding of its pathophysiology, none of the available therapies prevents disease progression. Excess glutamate plays an important role in excitotoxicity by activating ionotropic receptors. However, the mechanisms modulating neuronal cell survival/death via metabotropic glutamate receptors (mGluRs) are not completely understood. Recent data indicates that CDPPB, a positive allosteric modulator of mGluR5, has neuroprotective effects. Thus, this work aimed to investigate CDPPB treatment effects on amyloid-β (Aβ) induced pathological alterations in vitro and in vivo and in a transgenic mouse model of AD (T41 mice). Aβ induced cell death in primary cultures of hippocampal neurons, which was prevented by CDPPB. Male C57BL/6 mice underwent stereotaxic surgery for unilateral intra-hippocampal Aβ injection, which induced memory deficits, neurodegeneration, neuronal viability reduction and decrease of doublecortin-positive cells, a marker of immature neurons and neuronal proliferation. Treatment with CDPPB for 8 days reversed neurodegeneration and doublecortin-positive cells loss and recovered memory function. Fourteen months old T41 mice presented cognitive deficits, neuronal viability reduction, gliosis and Aβ accumulation. Treatment with CDPPB for 28 days increased neuronal viability (32.2% increase in NeuN+ cells) and reduced gliosis in CA1 region (Iba-1+ area by 31.3% and GFAP+ area by 37.5%) in transgenic animals, without inducing hepatotoxicity. However, it did not reverse cognitive deficit. Despite a four-week treatment did not prevent memory loss in aged transgenic mice, CDPPB is protective against Aβ stimulus. Therefore, this drug represents a potential candidate for further investigations as AD treatment.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentCOLTEC - COLEGIO TECNICOpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofNeuropharmacologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectAlzheimer's diseasept_BR
dc.subjectNeurodegenerationpt_BR
dc.subjectNeuroinflammationpt_BR
dc.subjectMetabotropic glutamate receptorspt_BR
dc.subjectAllosteric modulationpt_BR
dc.subjectCDPPBpt_BR
dc.subject.otherBioquímicapt_BR
dc.subject.otherFarmacologiapt_BR
dc.subject.otherAlzheimer, Doença dept_BR
dc.subject.otherSistema nervoso - Degeneraçãopt_BR
dc.subject.otherReceptores metabotrópicos de glutamato - Metabolismopt_BR
dc.subject.otherEnzimas alostéricaspt_BR
dc.titleA positive allosteric modulator of mGluR5 promotes neuroprotective effects in mouse models of Alzheimer's diseasept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0028390819303430pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6976-9633pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4855-3056pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0200-2902pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1701-4914pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8647-5108pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4147-5614pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3176-1681pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6974-3724pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4545-6821pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3631-1989pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5893-0831pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7042-9433pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3217-4294pt_BR
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