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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/63633
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dc.creatorAna María Garzón Porraspt_BR
dc.creatorBruna Silva Terrapt_BR
dc.creatorTaniris Cafiero Bragapt_BR
dc.creatorThais Furtado Ferreira Magalhãespt_BR
dc.creatorCleide Viviane Buzanello Martinspt_BR
dc.creatorDanielle Letícia da Silvapt_BR
dc.creatorLudmila de Matos Baltazarpt_BR
dc.creatorLudmila Ferreira Gouveiapt_BR
dc.creatorGustavo José Cota de Freitaspt_BR
dc.creatorDaniel de Assis Santospt_BR
dc.creatorMaria Aparecida de Resende Stoianoffpt_BR
dc.creatorBeth Burgwyn Fuchspt_BR
dc.creatorEleftherios Mylonakispt_BR
dc.creatorRossimiriam Pereira de Freitaspt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.date.accessioned2024-02-01T17:25:48Z-
dc.date.available2024-02-01T17:25:48Z-
dc.date.issued2018-
dc.citation.volume14pt_BR
dc.citation.spage81pt_BR
dc.citation.epage91pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jare.2018.06.004pt_BR
dc.identifier.issn2090-1232pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/63633-
dc.description.resumoThe incidence of fungal infections is considered a serious public health problem worldwide. The limited number of antimycotic drugs available to treat human and animal mycosis, the undesirable side effects and toxicities of the currently available drugs, and the emergence of fungal resistance emphasizes the urgent need for more effective antimycotic medicines. In this paper, we describe a rapid, simple, and efficient synthetic route for preparation of the antifungal agent butenafine on a multigram scale. This novel synthetic route also facilitated the preparation of 17 butenafine analogues using Schiff bases as precursors in three steps or less. All the synthesized compounds were evaluated against the yeast, Cryptococcus neoformans/C. gattii species complexes and the filamentous fungi Trichophyton rubrum and Microsporum gypseum. Amine 4bd, a demethylated analogue of butenafine, and its corresponding hydrochloride salt showed low toxicity in vitro and in vivo while maintaining inhibitory activity against filamentous fungi.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Advanced Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAntifungal activitypt_BR
dc.subjectButenafinept_BR
dc.subjectMicrowave-assisted synthesispt_BR
dc.subjectMultigram-scale synthesispt_BR
dc.subjectSchiff basept_BR
dc.subjectTrichophyton rubrumpt_BR
dc.subject.otherQuímicapt_BR
dc.subject.otherAtividade antifúngicapt_BR
dc.subject.otherAntimicóticopt_BR
dc.subject.otherSchiff, Bases dept_BR
dc.subject.otherDermatófitospt_BR
dc.subject.otherFungos filamentosospt_BR
dc.subject.otherMicrobiologia - Síntesespt_BR
dc.titleButenafine and analogues: an expeditious synthesis and cytotoxicity and antifungal activitiespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S209012321830078Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9578-7648pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4032-0100pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1447-6670pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4255-3047pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1108-5666pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6220-1321pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5233-1221pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4624-0777pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6974-3724pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
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