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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/64246
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dc.creatorVinicius Coelho Carrardpt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorManoela Domingues Martinspt_BR
dc.creatorFlorencia Dornellespt_BR
dc.creatorVivian Wagnerpt_BR
dc.creatorCarla Ariottipt_BR
dc.creatorVinicius Carrardpt_BR
dc.creatorPablo Vargaspt_BR
dc.creatorCeleste Sánchez-Romeropt_BR
dc.creatorVeronica Beovidept_BR
dc.date.accessioned2024-02-19T18:21:38Z-
dc.date.available2024-02-19T18:21:38Z-
dc.date.issued2021-
dc.citation.volume29pt_BR
dc.citation.issue5pt_BR
dc.citation.spage366pt_BR
dc.citation.epage373pt_BR
dc.identifier.doi10.1097/pai.0000000000000874pt_BR
dc.identifier.issn15412016pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/64246-
dc.description.resumoOdontogenic lesions (OL) are an important group of oral and maxillofacial diseases represented by odontogenic cysts, benign, and malignant tumors. The brain-derived neurotrophic factor (BDNF)/ tropomyosin receptor kinase B (TrkB) signaling pathway has multiple biological actions and has been identified as an important pathway in the proliferation, invasion, and survival of different epithelial tumors. Its role in the development of OL, however, has so far been unexplored. Our aim was to evaluate the BDNF/TrkB/Akt/p-RPS6 signaling pathway in OL of epithelial origin. This cross-sectional study comprised 3 cases of tooth germs, 25 cases of odontogenic keratocyst (OK), 29 cases of ameloblastoma (Am), and 6 cases of ameloblastic carcinoma. Immunohistochemical staining for BDNF, TrkB, p-Akt, and p-RPS6 was performed. OLs were evaluated according to the pattern of immunohistochemical expression in epithelial cells and by semiquantitative scores that considered the intensity of staining and percentage of positive cells. BDNF stromal expression was also assessed. No significant differences were observed with respect to the percentage of positive cases for all markers. Regarding the immunoreactive scores, BDNF and p-RPS6 expressions were similar in the odontogenic epithelium of all OL. However, TrkB and p-Akt were overexpressed in OK compared with ameloblastic carcinoma. In Am, epithelial BDNF was significantly higher compared with stromal expression. In conclusion, BDNF seems to participate in the development of cystic, benign, and malignant odontogenic epithelium to similar degrees. The acquisition of the invasive or malignant phenotype in odontogenic neoplasms is not associated with alterations in the BDNF/TrkB/Akt/RPS6 axis, which could be implicated in the differentiation process.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofApplied immunohistochemistry & molecular morphologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectTumores odontogênicos 5 depósitos de trabalhos de pós-graduação próximo depósito 01data de busca de publicação 21/12/2023 cheguei na hora 15h e 18min do dia 15 do 12 dezembro de 2023acesso restrito assunto Ameloblastoma fao clínica busca dia 01/12/2023 Bdnf/trkb/akt signaling pathway epithelial odontogenic tumors and keratocyst: an immunohistochemical study comparative with dental germspt_BR
dc.subjectcistos odontogênicos Key Words: odontogenic lesions, growth factor, signaling path way, mTOR, BDNF, TrkBpt_BR
dc.subjecttítulo periódico Applied immunohistochemistry & molecular morphologypt_BR
dc.subject5 depósitos de trabalhos de pós-graduação próximo depósito 01data de busca de publicação 21/12/2023 cheguei na hora 15h e 18min do dia 15 do 12 dezembro de 2023acesso restrito assunto Ameloblastoma fao clínica busca dia 01/12/2023 Bdnf/trkb/akt signaling pathway epithelial odontogenic tumors and keratocyst: an immunohistochemical study comparative with dental germspt_BR
dc.subject.otherAmeloblastomapt_BR
dc.subject.otherSignal transductionpt_BR
dc.subject.otherBrain-derived neurotrophic factorpt_BR
dc.subject.otherReceptor, trkBpt_BR
dc.subject.otherProteinspt_BR
dc.subject.otherPhosphorylationpt_BR
dc.subject.otherRibosomal protein S6pt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherNeoplasmspt_BR
dc.subject.otherOdontogenic cystspt_BR
dc.titleBDNF/trkb/akt signaling pathway epithelial odontogenic tumors and keratocyst: an immunohistochemical study comparative with dental germspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.lww.com/appliedimmunohist/fulltext/2021/05000/bdnf_trkb_akt_signaling_pathway_epithelial.6.aspxpt_BR
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