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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/66191
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Campo DCValorIdioma
dc.creatorSarah Leao Fiorini de Aguiarpt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorPatrícia Aparecida Barrospt_BR
dc.creatorTatiani Uceli Maiolipt_BR
dc.creatorAna Maria Caetano Fariapt_BR
dc.creatorMariana Camila Gonçalves Mirandapt_BR
dc.creatorMauro Andrade Freitas Guimarãespt_BR
dc.creatorHelton Costa Santiagopt_BR
dc.creatorCamila Pereira Queirozpt_BR
dc.creatorPricila da Silva Cunhapt_BR
dc.creatorDenise Carmona Carapt_BR
dc.creatorGiselle Foureauxpt_BR
dc.creatorAnderson José Ferreirapt_BR
dc.date.accessioned2024-03-20T20:09:40Z-
dc.date.available2024-03-20T20:09:40Z-
dc.date.issued2018-01-14-
dc.citation.volume8pt_BR
dc.citation.spage1969pt_BR
dc.citation.epage12pt_BR
dc.identifier.doihttps://doi.org/10.3389/fimmu.2017.01969pt_BR
dc.identifier.issn1664-3224pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/66191-
dc.description.resumoExcess intake of sodium is often associated with high risk for cardiovascular disease. More recently, some studies on the effects of high-salt diets (HSDs) have also demonstrated that they are able to activate Th17 cells and increase severity of autoimmune diseases. The purpose of the present study was to evaluate the effects of a diet supplemented with NaCl in the colonic mucosa at steady state and during inflammation. We showed that consumption of HSD by mice triggered a gut inflammatory reaction associated with IL-23 production, recruitment of neutrophils, and increased frequency of the IL-17-producing type 3 innate lymphoid cells (ILC3) in the colon. Moreover, gut inflammation was not observed in IL-17–/– mice but it was present, although at lower grade, in RAG−/− mice suggesting that the inflammatory effects of HSD was dependent on IL-17 but only partially on Th17 cells. Expression of SGK1, a kinase involved in sodium homeostasis, increased 90 min after ingestion of 50% NaCl solution and decreased 3 weeks after HSD consumption. Colitis induced by oral administration of either dextran sodium sulfate or 2,4,6-trinitrobenzenesulfonic acid was exacerbated by HSD consumption and this effect was associated with increased frequencies of RORγt+ CD4+ T cells and neutrophils in the colon. Therefore, our results demonstrated that consumption of HSD per se triggered a histologically detectable inflammation in the colon and also exacerbated chemically induced models of colitis in mice by a mechanism dependent on IL-17 production most likely by both ILC3 and Th17 cells.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENF - DEPARTAMENTO DE NUTRIÇÃOpt_BR
dc.publisher.departmentENFERMAGEM - ESCOLA DE ENFERMAGEMpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Immunologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSodium chloridept_BR
dc.subjectGut inflammationpt_BR
dc.subjectIL-17pt_BR
dc.subjectTh17 cellspt_BR
dc.subjectILC3pt_BR
dc.subject.otherCélulas Th17pt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherInterleucina-17pt_BR
dc.subject.otherCloreto de Sódiopt_BR
dc.titleHigh-Salt Diet Induces IL-17-Dependent Gut Inflammation and Exacerbates Colitis in Micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01969/fullpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7538-3208pt_BR
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