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http://hdl.handle.net/1843/66319| Type: | Artigo de Periódico |
| Title: | Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition |
| Authors: | Ana Carolina Sena Avellar Mariana Naves Oliveira Felipe Caixeta Rafaela Cristina Vieira e Souza Elaine Speziali Faria Andréa Teixeira Ana Maria Caetano Faria Gabriela Silveira Nunes Tatiani Uceli Maioli |
| Abstract: | Breast milk is considered a complete food for babies. Up to 7 days postpartum, it is known as colostrum, rich in immunological compounds, responsible for providing nutrition and ensuring immune protection. However, some maternal factors, such as gestational diabetes mellitus (GDM), can change the concentration of bioactive compounds present in the colostrum and may affect the development of the newborn’s immune system. The effect of GDM on colostrum cytokine, chemokine, and growth factors is not well described. Thus, the present study evaluated whether the occurrence of GDM changes the concentration of biomarkers in the colostrum. A cross-sectional study was carried out on postpartum women who had healthy pregnancies and women who had been diagnosed with GDM. A sample of colostrum was collected for Luminex analysis. Our results showed that GDM mothers had higher secretion of cytokines and chemokines in the colostrum, with a higher concentration of IFN-g, IL-6, and IL-15, and a lower concentration of IL-1ra. Among growth factors, we identified a decreased concentration of GM-CSF in the colostrum of GDM mothers. Thus, the data obtained support the idea that the disease leads to immune alterations in the colostrum. |
| Subject: | Diabetes Mellitus Gravidez Colostro Sistema Imunitário Citocinas Quimiocinas Peptídeos e Proteínas de Sinalização Intercelular |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ENF - DEPARTAMENTO DE NUTRIÇÃO ENFERMAGEM - ESCOLA DE ENFERMAGEM ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.3389/fimmu.2022.910807 |
| URI: | http://hdl.handle.net/1843/66319 |
| Issue Date: | 19-Jun-2022 |
| metadata.dc.url.externa: | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.910807/full |
| metadata.dc.relation.ispartof: | Frontiers in Immunology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Gestational Diabetes Mellitus Changes Human Colostrum Immune Composition.pdf | 1.73 MB | Adobe PDF | View/Open |
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