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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/68150
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Campo DCValorIdioma
dc.creatorJames Varnipt_BR
dc.creatorRobert Shulmanpt_BR
dc.creatorMariella Selfpt_BR
dc.creatorShehzad Saeedpt_BR
dc.creatorAshish Patelpt_BR
dc.creatorSamuel Nurkopt_BR
dc.creatorDeborah Neigutpt_BR
dc.creatorMiguel Sapspt_BR
dc.creatorJames Franciosipt_BR
dc.creatorJolanda Denhampt_BR
dc.creatorGeorge Zacurpt_BR
dc.creatorChelsea Darkpt_BR
dc.creatorCristiane Baccin Bendo Nevespt_BR
dc.creatorJohn Pohlpt_BR
dc.date.accessioned2024-05-09T18:17:33Z-
dc.date.available2024-05-09T18:17:33Z-
dc.date.issued2016-12-
dc.citation.volume63pt_BR
dc.citation.issue6pt_BR
dc.citation.spagee186pt_BR
dc.citation.epagee192pt_BR
dc.identifier.doihttps://doi.org/10.1097/MPG.0000000000001428pt_BR
dc.identifier.issn0277-2116pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/68150-
dc.description.resumoObjectives: The aim of the study was to investigate the multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with inflammatory bowel disease from the perspectives of pediatric patients and parents. Methods: The Pediatric Quality of Life Inventory Gastrointestinal Symptoms Scales and Pediatric Quality of Life Inventory 4.0 Generic Core Scales were completed in a 9-site study by 260 families of patients with inflammatory bowel disease. Gastrointestinal Symptoms Scales measuring stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were identified as clinically important symptom differentiators from healthy controls based on prior findings, and subsequently tested for bivariate and multivariate linear associations with overall HRQOL (Generic Core Scales). Results: Stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were significantly associated with decreased HRQOL in bivariate analyses (P < 0.001). In predictive models utilizing hierarchical multiple regression analyses controlling for age, sex, and race/ethnicity, gastrointestinal symptoms accounted for an additional 40% of the variance in patient self-reported HRQOL (P < 0.001) and 37% of the variance in parent proxy-reported HRQOL (P < 0.001), reflecting large effect sizes. Stomach pain, food and drink limits, and constipation were significant individual patient-reported predictors after controlling for the other gastrointestinal symptoms in the predictive models. Conclusions: Patient-reported gastrointestinal symptoms differentially predicted HRQOL. Identifying the specific gastrointestinal symptoms from a standardized multidimensional gastrointestinal symptoms profile that are the most important predictors from the patient perspective facilitates a patient-centered approach for interventions designed to ameliorate impaired HRQOL.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition-
dc.rightsAcesso Restritopt_BR
dc.subjectCrohn diseasept_BR
dc.subjectGastrointestinal symptomspt_BR
dc.subjectInflammatory bowel diseasept_BR
dc.subjectPatient-reported outcomespt_BR
dc.subjectPedsQLpt_BR
dc.subjectUlcerative colitispt_BR
dc.subject.otherCrohn diseasept_BR
dc.subject.otherLocal symptomspt_BR
dc.subject.otherInflammatory bowel diseasespt_BR
dc.subject.otherPatient reported outcome measurespt_BR
dc.subject.otherIndicators of quality of lifept_BR
dc.subject.otherColitis, ulcerativept_BR
dc.titleGastrointestinal symptoms predictors of health-related quality of life in patients with inflammatory bowel diseasept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1097/MPG.0000000000001428pt_BR
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