1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/68188
Full metadata record
DC FieldValueLanguage
dc.creatorJames Varnipt_BR
dc.creatorRobert Shulmanpt_BR
dc.creatorMariella Selfpt_BR
dc.creatorSamuel Nurkopt_BR
dc.creatorMiguel Sapspt_BR
dc.creatorShehzad Saeedpt_BR
dc.creatorAshish Patelpt_BR
dc.creatorChelsea Vaughan Darkpt_BR
dc.creatorCristiane Baccin Bendo Nevespt_BR
dc.creatorJohn Pohlpt_BR
dc.date.accessioned2024-05-10T18:37:21Z-
dc.date.available2024-05-10T18:37:21Z-
dc.date.issued2017-04-
dc.citation.volume26pt_BR
dc.citation.issue4pt_BR
dc.citation.spage1015pt_BR
dc.citation.epage1025pt_BR
dc.identifier.doihttps://doi.org/10.1007/s11136-016-1430-3pt_BR
dc.identifier.issn1573-2649pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/68188-
dc.description.resumoObjectives: To investigate the patient-reported multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with functional gastrointestinal disorders (FGIDs). Methods: The Pediatric Quality of Life Inventory™ (PedsQL™) Gastrointestinal Symptoms Scales and PedsQL™ 4.0 Generic Core Scales were completed in a 9-site study by 259 pediatric patients with functional constipation, functional abdominal pain (FAP), or irritable bowel syndrome (IBS). Gastrointestinal Symptoms Scales measuring stomach pain, stomach discomfort when eating, food and drink limits, trouble swallowing, heartburn and reflux, nausea and vomiting, gas and bloating, constipation, blood in poop, and diarrhea were identified as clinically important symptom differentiators from healthy controls based on prior findings, and subsequently tested for bivariate and multivariate linear associations with overall HRQOL. Results: Gastrointestinal symptoms were differentially associated with decreased HRQOL in bivariate analyses for the three FGIDs. In predictive models utilizing hierarchical multiple regression analyses controlling for age, gender, and race/ethnicity, gastrointestinal symptoms differentially accounted for an additional 47, 40, and 60 % of the variance in patient-reported HRQOL for functional constipation, FAP, and IBS, respectively, reflecting large effect sizes. Significant individual gastrointestinal symptoms predictors were identified after controlling for the other gastrointestinal symptoms in the FGID-specific predictive models. Conclusions: Gastrointestinal symptoms represent potentially modifiable predictors of generic HRQOL in pediatric patients with FGIDs. Identifying the condition-specific gastrointestinal symptoms that are the most important predictors from the patient perspective facilitates a patient-centered approach to targeted interventions designed to ameliorate impaired overall HRQOL.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofQuality of Life Research-
dc.rightsAcesso Restritopt_BR
dc.subjectIrritable bowel syndromept_BR
dc.subjectFunctional constipationpt_BR
dc.subjectFunctional abdominal painpt_BR
dc.subjectGastrointestinal symptomspt_BR
dc.subjectPatient-reported outcomespt_BR
dc.subjectPedsQLpt_BR
dc.subject.otherIrritable bowel syndromept_BR
dc.subject.otherConstipationpt_BR
dc.subject.otherAbdominal painpt_BR
dc.subject.otherLocal symptomspt_BR
dc.subject.otherPatient reported outcome measurespt_BR
dc.subject.otherIndicators of quality of lifept_BR
dc.titleGastrointestinal symptoms predictors of health-related quality of life in pediatric patients with functional gastrointestinal disorderspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s11136-016-1430-3pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.