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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/70470
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Campo DCValorIdioma
dc.creatorLilian Areal Marquespt_BR
dc.creatorSimone Cristine Semprebonpt_BR
dc.creatorDaniele Sartoript_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorLúcia Regina Ribeiropt_BR
dc.creatorMário Sérgio Mantovanipt_BR
dc.date.accessioned2024-07-12T19:55:45Z-
dc.date.available2024-07-12T19:55:45Z-
dc.date.issued2017-
dc.citation.volume37pt_BR
dc.citation.issue3pt_BR
dc.citation.spage1197pt_BR
dc.citation.epage1204pt_BR
dc.identifier.doihttps://doi.org/10.21873/anticanres.11434pt_BR
dc.identifier.issn1791-7530pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/70470-
dc.description.resumoMonastrol and its analog oxomonastrol differ by replacement of the sulfur atom present in monastrol to an oxygen atom in oxomonastrol. Monastrol inhibits the mitotic kinesin family member 11 (EG5), which has been studied for its potential use in cancer therapy. The aim of this study was to investigate the effect of monastrol and oxomonastrol on HepG2/C3A cells. Our results showed that monastrol induced DNA damage, reduced cell proliferation, and up-regulated the cytochrome P450 family 1 subfamily A member 1 (CYP1A1) mRNA levels. However, oxomonastrol was cytotoxic only at the highest concentrations used, without reducing cell proliferation and viability. Moreover, no genotoxic damage or alteration of levels of mRNA were found. Our results suggest that monastrol has greater antiproliferative activity compared to oxomonastrol, and this effect is probably related to the DNA damage induced by monastrol and its possible bioactivation demonstrated by the increase in CYP1A1 mRNA expression. Moreover, these effects appear to be related to the presence of the sulfur atom in its structure.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAnticancer Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMonastrolpt_BR
dc.subjectOxo-monastrolpt_BR
dc.subjectHuman hepatoma cell linept_BR
dc.subjectAnticancer activitypt_BR
dc.subject.otherMorfologiapt_BR
dc.subject.otherQuímicapt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.subject.otherApoptosept_BR
dc.subject.otherTestes biológicospt_BR
dc.subject.otherMicroscopia de fluorescênciapt_BR
dc.subject.otherCâncer - Quimioterapiapt_BR
dc.titleComparison of the effects of monastrol and oxomonastrol on human hepatoma cell line HepG2/C3Apt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://ar.iiarjournals.org/content/37/3/1197/tab-article-infopt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7550-8509pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0465-9932pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9857-8681pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5268-6508pt_BR
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