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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/71188
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dc.creatorFernando Oliveira Costapt_BR
dc.creatorSheila Cavalca Cortellipt_BR
dc.creatorTarcília Aparecida Silvapt_BR
dc.creatorAmanda Almeida Costapt_BR
dc.creatorRafael Paschoal Esteves Limapt_BR
dc.creatorJosé Roberto Cortellipt_BR
dc.creatorLuís Otávio de Miranda Cotapt_BR
dc.date.accessioned2024-07-22T19:47:55Z-
dc.date.available2024-07-22T19:47:55Z-
dc.date.issued2018-12-11-
dc.citation.volume23pt_BR
dc.citation.spage3517pt_BR
dc.citation.epage3526pt_BR
dc.identifier.doihttps://doi.org/10.1007/s00784-018-2770-xpt_BR
dc.identifier.issn1436-3771pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/71188-
dc.description.resumoObjectives To longitudinally evaluate the effects of compliance during periodontal maintenance therapy (PMT) on cytokines levels and its relation to periodontal status. Materials and methods Ninety-one eligible individuals were selected from a 6-year prospective study with 212 individuals in PMT. From this total, 28 regular compliers (RC) were randomly selected and matched for age and gender with 28 irregular compliers (IC). All participants were non-smokers and non-diabetic. Periodontal parameters and gingival crevicular fluid samples were collected in 5 times: T1 [prior to active periodontal therapy (APT)], T2 (after APT), T3 (2 years), T4 (4 years), and T5 (6 years). Levels of IL-6, IL-10, IL-1β, TNF-α, and MMP-8 were quantified through ELISA. Results RC presented better clinical periodontal status over time when compared to IC. A significant reduction in the levels of IL-1β, TNF-α, MMP-8, and IL-6 was observed among RC along time (from T1 to T5). Levels of IL-1 were similar among groups. By contrast, levels of IL-6 and TNF-α increased over time in IC individuals. Levels of IL-10 increased among RC and reduced among IC. Conclusions The inflammatory cytokines IL-1, TNF-α, IL-6, and MMP-8 were correlated with worse clinical parameters among IC, while IL-10 was associated with an improvement in clinical parameters among RC. These results reinforce the role of these cytokines in the pathogenesis of periodontitis, as well as their role as markers to monitoring the progression of the periodontitis. Clinical relevance Regular compliance during 6-year period the PMT sustained clinical and immunological benefits obtained after active periodontal therapy.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinical Oral Investigationspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectCompliancept_BR
dc.subjectClinical Oral Investigationspt_BR
dc.subjectacesso restrito Luís Otávio de Miranda Cota último professor buscado.Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy busca dia 19/07/2024 julho hora 15 e 01 fao clínicapt_BR
dc.subject.otherCytokinespt_BR
dc.subject.otherCompliancept_BR
dc.subject.otherMaintenancept_BR
dc.subject.otherPeriodontitispt_BR
dc.subject.otherBiomarkerspt_BR
dc.subject.otherImmune systempt_BR
dc.title.Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s00784-018-2770-xpt_BR
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