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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/71978
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dc.creatorDarliane Aparecida Martinspt_BR
dc.creatorLucius Flavius Ourives Bomfim Filhopt_BR
dc.creatorCleiton Moreira da Silvapt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorSônia Renaux Wanderley Louropt_BR
dc.creatorDenise da Gama Jaen Batistapt_BR
dc.creatorMaria de Nazaré Correia Soeiropt_BR
dc.creatorJoão Ernesto de Carvalhopt_BR
dc.creatorLetícia Regina de Souza Teixeirapt_BR
dc.date.accessioned2024-07-26T23:33:46Z-
dc.date.available2024-07-26T23:33:46Z-
dc.date.issued2017-
dc.citation.volume28pt_BR
dc.citation.issue1pt_BR
dc.citation.spage87pt_BR
dc.citation.epage97pt_BR
dc.identifier.doihttp://dx.doi.org/10.5935/0103-5053.20160150pt_BR
dc.identifier.issn0103-5053pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/71978-
dc.description.resumoCopper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino)phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)].0.5H2O and [CuCl(L2)(phen)].2H2O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)].0.5H2O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiropt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of the Brazilian Chemical Societypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSchiff basept_BR
dc.subjectCopper(II) complexespt_BR
dc.subjectBiological activitypt_BR
dc.subjectDNApt_BR
dc.subjectAlbuminpt_BR
dc.subject.otherSchiff, Bases dept_BR
dc.subject.otherCompostos de cobrept_BR
dc.subject.otherTestes biológicospt_BR
dc.subject.otherDNApt_BR
dc.subject.otherAlbuminapt_BR
dc.titleCopper(II) nitroaromatic schiff base complexes: synthesis, biological activity and their interaction with dna and albuminspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://jbcs.sbq.org.br/default.asp?ed=247pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5102-4633pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9913-8971pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5208-4144pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3790-572Xpt_BR
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