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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/72460
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Campo DCValorIdioma
dc.creatorPriscila Laiza Rubim Leãopt_BR
dc.creatorHelvécio Marangon Juniorpt_BR
dc.creatorVictória Vasconcellos Moreira Melopt_BR
dc.creatorÂngela Braga Caixetapt_BR
dc.creatorPaulo Eduardo Alencar Souzapt_BR
dc.creatorMaria Cassia Ferreira de Aguiarpt_BR
dc.creatorMartinho Campolina Rebello Hortapt_BR
dc.date.accessioned2024-08-02T19:26:43Z-
dc.date.available2024-08-02T19:26:43Z-
dc.date.issued2017-
dc.citation.volume46 Journal of oral pathology & medicinept_BR
dc.citation.issue10pt_BR
dc.citation.spage949pt_BR
dc.citation.epage955pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.12578pt_BR
dc.identifier.issn1600-0714pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/72460-
dc.description.resumoBackground: This study aimed to analyze the reproducibility, repeatability, and level of difficulty of two methods for tumor budding evaluation in oral squamous cell carcinoma (OSCC): staining by hematoxylin and eosin (HE) and immunostaining for multicytokeratin. Methods: The evaluation of tumor budding was performed by three examiners in 103 samples of OSCC, using the two methods. A Likert-type scale was used to measure the difficulty in the assessment. The interexaminer agreement (reproducibility) was estimated using Fleiss's kappa and the intra-examiner agreement (repeatability) was estimated using Cohen's kappa. The agreement between the two methods was evaluated using Cohen's Kappa. The Friedman test was used to compare the three examiners' perceived levels of difficulty of assessment. The Wilcoxon test was used to compare the level of difficulty of the evaluation between the two methods. Results: Reproducibility by the immunostaining method for multicytokeratin was substantial, being higher than the only fair agreement by the HE. Repeatability by the HE ranged from moderate to substantial among examiners, regardless of the examiner's experience. Repeatability by the immunostaining method for multicytokeratin did not vary among examiners, showing almost perfect agreement. The agreement between the two methods ranged from fair to moderate among examiners, being lower in the less experienced examiner. All the examiners presented greater difficulty in the evaluation by the HE. Conclusion: In view of the unsatisfactory agreement between the two methods of tumor budding evaluation in OSCC, it is recommended that this evaluation should be performed by the immunostaining method for multicytokeratin, considering its higher reproducibility, greater replicability, and lower difficulty compared to the HE.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology & Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectoral squamous cell carcinomapt_BR
dc.subjectbuddingpt_BR
dc.subject.otherMouth neoplasmspt_BR
dc.subject.otherSquamous cell carcinoma of head and neckpt_BR
dc.subject.otherColorpt_BR
dc.subject.otherImmune systempt_BR
dc.subject.otherHematoxylinpt_BR
dc.subject.otherKeratinspt_BR
dc.subject.otherReproducibility of resultspt_BR
dc.subject.otherEvaluation studypt_BR
dc.subject.otherReplica techniquespt_BR
dc.titleReproducibility, repeatability and level of difficulty of two methods for tumor budding evaluation in oral squamous cell carcinomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12578pt_BR
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