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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/72495
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dc.creatorHumberto Moreira Spindolapt_BR
dc.creatorRogério Grandopt_BR
dc.creatorMariana Cecchetto Figueiredopt_BR
dc.creatorRosanna Tarkany Bastingpt_BR
dc.creatorNúbia de Cássia Almeida Queirozpt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorJoão Ernesto de Carvalhopt_BR
dc.creatorZaijie Jim Wangpt_BR
dc.creatorMary Ann Fogliopt_BR
dc.date.accessioned2024-08-02T21:34:51Z-
dc.date.available2024-08-02T21:34:51Z-
dc.date.issued2017-
dc.citation.volume804pt_BR
dc.citation.spage68pt_BR
dc.citation.epage77pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ejphar.2017.03.030pt_BR
dc.identifier.issn0014-2999pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/72495-
dc.description.resumoPterodon genus fruits are commercially available at the Brazilian medicinal market used in folk medicine due to their anti-inflammatory, analgesic, and anti-rheumatic effects. Previous studies demonstrated that furanditerpenes possessing vouacapan skeleton, isolated from Pterodon genus, possess expressive antinociceptive activities, with promising moiety for the development of new analgesic products. The antinociceptive properties of compounds 6α,7β-6α-hidroxivouacapan-7β-17β-lactone (HVL) and 6α-oxovouacapan-7β-17β-lactone (OVL), semi-synthetic analogues of furanditerpenes previously reported as analgesic agents were evaluated on animal experimental models (Spindola et al., 2010, 2011). The chemical-induced pain methods used in the present work, demonstrated for the first time that both compounds HVL and OVL have potential as important templates for the development of chronic pain control drugs. The main findings of this work were that both compounds were: effective in the writhing test; reduced paw edema in the carrageenan test; effective in the inflammatory phase of the formalin test corroborating their activity against inflammatory pain conditions; effective on reducing pain through the stimulation of vanilloid receptors sensible to capsaicin (an important pathway for chronic pain maintenance); reduced the pain stimulus caused by PGE2 injection (a pathway involved in chronic pain hypersensitivity); effective on decreasing mechanical allodynia in the CFA-model, demonstrating their potential use against chronic pain disorders.pt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Journal of Pharmacologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectAnalgesicspt_BR
dc.subjectFuranditerpenespt_BR
dc.subjectBrazilian florapt_BR
dc.subjectAnti-inflammatorypt_BR
dc.subject.otherBioquímicapt_BR
dc.subject.otherQuímicapt_BR
dc.subject.otherDiterpenospt_BR
dc.subject.otherPlantas medicinaispt_BR
dc.subject.otherAnalgésicospt_BR
dc.subject.otherDor intratávelpt_BR
dc.titleDerivatives of furanditerpenes from Pterodon genus: pharmacological studies disclose their potential as chronic pain relief in micept_BR
dc.title.alternativept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0014299917302030?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0009-0004-8142-3650pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7513-102Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7231-4680pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1510-5684pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3496-4655pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0008-5478-0977pt_BR
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