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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/72500
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Campo DCValorIdioma
dc.creatorJoão Ernesto de Carvalhopt_BR
dc.creatorJosué Carinhanha Caldas Santospt_BR
dc.creatorIsis Martins Figueiredopt_BR
dc.creatorRosemeire Brondi Alvespt_BR
dc.creatorLuzia Valentina Modolopt_BR
dc.creatorCleiton Moreira da Silvapt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorMarina de Magalhães Silvapt_BR
dc.creatorFabiano Souza Reispt_BR
dc.creatorAna Lucia Tasca Gois Ruizpt_BR
dc.date.accessioned2024-08-03T00:39:38Z-
dc.date.available2024-08-03T00:39:38Z-
dc.date.issued2017-
dc.citation.volume172pt_BR
dc.citation.spage129pt_BR
dc.citation.epage138pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jphotobiol.2017.05.020pt_BR
dc.identifier.issn1011-1344pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/72500-
dc.description.resumoThirty-nine Schiff bases were synthesized by performing microwave-assisted condensation of the corresponding aldehydes and aromatic amines. Their reactive nitrogen species (RNS) scavenging activity and inhibitory effects against cancer cell growth were then subsequently investigated. Additionally, the interaction between the calf thymus DNA (ctDNA) and selected Schiff bases was evaluated using fluorescence spectroscopy, and their binding parameters were determined. The yields of the various compounds ranged from moderate to excellent (43–99%) after only a 2-min reaction. The hydroxylated Schiff bases 2, 8, 15, 16, 18, 20, 29, 32, 34, and 37 were found to be potent scavengers of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals with half-maximal scavenging concentration (SC50) values lower than that of the positive control, resveratrol. The presence of hydroxyl substituents on the aromatic rings also proved essential to the cytotoxicity of the compounds. The binding constants (Kb) obtained using fluorescence spectroscopy ranged from 0.37 to 3.07 × 105 L mol− 1, and were strongly influenced by the structure and hydroxylation degree. Schiff bases 3 and 8 showed promising cytotoxic activity, with half-maximal growth inhibitory (GI50) values in the same order of magnitude as those exhibited by the reference drug, doxorubicin against various cell lines. Interestingly, these compounds also showed the highest Kb, suggesting that the cytotoxic activity could be related to their interaction with the DNA of the tumor cells. The results of this study highlighted some Schiff bases as potential lead compounds for the design of new free radical scavengers and anticancer agents.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Photochemistry and Photobiology B: Biologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectSchiff basespt_BR
dc.subjectMicrowave-assisted synthesispt_BR
dc.subjectFree radical scavengingpt_BR
dc.subjectAntiproliferative activityctpt_BR
dc.subjectDNA interactionpt_BR
dc.subjectCancer cellspt_BR
dc.subject.otherSchiff, Bases dept_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.subject.otherCélulas cancerosaspt_BR
dc.subject.otherReações de radicais livrespt_BR
dc.subject.otherAldeídospt_BR
dc.subject.otherAminaspt_BR
dc.subject.otherDNApt_BR
dc.subject.otherCitotoxidade de mediação celularpt_BR
dc.titleStudies on free radical scavenging, cancer cell antiproliferation, and calf thymus DNA interaction of schiff basespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1011134417302233pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6901-6815pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9525-5123pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1873-5342pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0546-2549pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8033-0434pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9913-8971pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1087-4639pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2256-4379pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0844-8702pt_BR
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