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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/72580
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Campo DCValorIdioma
dc.creatorJoana C. da Silvapt_BR
dc.creatorJuliana Barbosa Nunespt_BR
dc.creatorVanessa Silva Gontijopt_BR
dc.creatorVanessa Silva Gontijopt_BR
dc.creatorRossimiriam Pereira de Freitaspt_BR
dc.creatorRosemeire Brondi Alvespt_BR
dc.creatorFábio Antônio Colombopt_BR
dc.creatorMarcia Dalastra Laurentipt_BR
dc.creatorMarcos José Marquespt_BR
dc.date.accessioned2024-08-05T14:48:09Z-
dc.date.available2024-08-05T14:48:09Z-
dc.date.issued2020-
dc.citation.volume209pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.actatropica.2020.105539pt_BR
dc.identifier.issn1873-6254pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/72580-
dc.description.resumoVisceral leishmaniasis (VL) is a chronic and systemic disease; if untreated, it can cause death in a large number of cases. The therapy is based on the use of antimonials, which have been used for over 50 years. However, cases of resistance have been reported in some countries. In this context, miltefosine (MIL) was introduced to treat antimonial unresponsive cases. Nonetheless, in recent years MIL unresponsive and relapse cases of VL have increasingly been reported. In the current study, the therapeutic potential of compound 5-(4-(3-methanesulfonatepropyl)-1H-1,2,3-triazol-1-yl)dodecyl methanesulfonate (C11), an MIL derivative, was assessed in an experimental VL hamster model. For this purpose, golden hamsters (Mesocricetus auratus) were infected with Leishmania (L.) infantum chagasi and treated daily for 10 days with C11 and MIL administered orally; in addition, Glucantime (GLU), peritoneal route, were administered at 15, 10, 50 mg/kg body weight/day, respectively. Twenty four hours after the end of treatment the animals were euthanatized; and the specimens were collected to evaluate the relative mRNA expression of cytokines IFN-γ, TNF-α, IL-17, TGF-β, IL-4 and IL-10 in fragments of the spleen and liver; moreover, the parasitism in these organs was evaluated as well as the main histopathological alterations. The C11-treated animals showed greater expression of IL-17 and TNF-α cytokines and reduced expression of IL-10 in the spleen in comparison to the infected untreated group (UTG) (p <0.05). The C11 and GLU groups showed a significant reduction in the IgG levels in comparison to the UTG group (p <0.05). Moreover, the C11-treated animals had fewer parasites in the spleen than the UTG animals (reduction of 95.9%), as well as a greater preservation of white pulp architecture in the spleen than the UTG, GLU and MIL groups (p <0.05). For the liver, the animals from the C11 and MIL groups showed a significant increase in TNF-α relative expression in comparison to the UTG animals, which would explain the increase in the number of granulomas and the reduction in the parasitic load (p <0.05). Combined, these findings indicate that C11 is an interesting compound that should be considered for the development of new drugs against VL, mainly due to its leishmanicidal effect and immunostimulating action.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofActa Tropicapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMiltefosine derivativept_BR
dc.subjectExperimental treatmentpt_BR
dc.subjectVisceral leishmaniasispt_BR
dc.subjectImmune responsept_BR
dc.subject.otherQuímica farmacêuticapt_BR
dc.subject.otherLeishmaniose visceralpt_BR
dc.subject.otherResposta imunept_BR
dc.titleLeishmanicidal activity in vivo of a miltefosine derivative in Mesocricetus auratuspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0001706X19314895pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2628-0357pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1674-818Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4920-072Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6974-3724pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0546-2549pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1596-9709pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1080-2440pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3459-3169pt_BR
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