1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/72668
Registro completo de metadados
Campo DCValorIdioma
dc.creatorSuelen Teixeira Luizpt_BR
dc.creatorRafaela Scariot de Moraespt_BR
dc.creatorMaria Cassia Ferreira de Aguiarpt_BR
dc.creatorSérgio Aparecido Ignáciopt_BR
dc.creatorBruno Correia Jhampt_BR
dc.creatorLucia de Noronhapt_BR
dc.creatorAline Cristina Batista Rodrigues Johannpt_BR
dc.creatorFilipe Modolo Siqueirapt_BR
dc.creatorIzabela Mozzerpt_BR
dc.creatorEmanuela Carla dos Santospt_BR
dc.creatorSeigo Nagashimapt_BR
dc.creatorAna Paula Camargo Martinspt_BR
dc.creatorMarina Luise Viola de Azevedopt_BR
dc.creatorLuciana Reis Azevedo Alanispt_BR
dc.creatorAna Maria Grégio Hardypt_BR
dc.date.accessioned2024-08-05T21:12:13Z-
dc.date.available2024-08-05T21:12:13Z-
dc.date.issued2018-
dc.citation.volume24 Oral diseasespt_BR
dc.citation.issue8pt_BR
dc.citation.spage1449pt_BR
dc.citation.epage1457pt_BR
dc.identifier.doihttps://doi.org/10.1111/odi.12922pt_BR
dc.identifier.issn1601-0825pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/72668-
dc.description.resumoObjective: This study was conducted to correlate and compare the immunoexpression of sex-determining region Y-box 2 (SOX-2) in oral leukoplakia (OL) lesions with that in normal buccal mucosa (control). Materials and methods: In this observational study, OL with low-risk (n = 34) and high-risk (n = 33) dysplasia and control samples (n = 25) were subjected to immunohistochemical analysis for SOX-2. In the epithelium, SOX-2 positive and negative cells, as well as semiautomatic segmentation of the immunopositive nuclear area were counted. Statistical tests included chi-square, one-way analysis of variance, Tukey, and Games-Howell. The level of significance was 5%. Results: Groups with OL lesions (low and high-risk) showed higher mean numbers of SOX-2 positive cells (63.47 ± 25.70 and 68.18 ± 21.17) compared to the control group (45.85 ± 27.38) (p = 0.00). Groups with OL lesions (low and high-risk) exhibited higher mean positive nuclear area (0.24 ± 0.47 and 1.09 ± 2.06) compared to the control group (0.00 ± 0.01) (p = 0.01). Conclusion: Oral leukoplakia lesions showed a higher expression of SOX-2, suggesting its contribution to the pathogenesis of OL.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Diseasespt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectleukoplakiapt_BR
dc.subjectimmunohistochemistrypt_BR
dc.subjectsox2pt_BR
dc.subject.otherMouthpt_BR
dc.subject.otherLeukoplakiapt_BR
dc.subject.otherMouth neoplasmspt_BR
dc.subject.otherSOXB2 transcription factorspt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherImmune systempt_BR
dc.subject.otherGene expressionpt_BR
dc.titleImmunoexpression of SOX-2 in oral leukoplakiapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/odi.12922pt_BR
Aparece nas coleções:Artigo de Periódico

Arquivos associados a este item:
Não existem arquivos associados a este item.
Mostrar registro simples do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.