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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/73338
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dc.creatorLuiza Guimarães Tunespt_BR
dc.creatorVivian Nicolau Gonçalvespt_BR
dc.creatorDaniela Nabak Buenopt_BR
dc.creatorCarlos Leomar Zanipt_BR
dc.creatorLuiz Henrique Rosapt_BR
dc.creatorBetania Barros Cotapt_BR
dc.date.accessioned2024-08-07T21:49:48Z-
dc.date.available2024-08-07T21:49:48Z-
dc.date.issued2019-
dc.citation.volume13pt_BR
dc.citation.issue28pt_BR
dc.citation.spage562pt_BR
dc.citation.epage567pt_BR
dc.identifier.issn19960808pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/73338-
dc.description.abstractFracionamento cromatográfico do extrato antileishmania obtido da fermentação do fungo endofítico Penicillium citrinum, isolado de folhas de Ageratum myriadenia, rendeu três alcalóides de dicetopiperazina; ciclo(L-Pro-L-Leu) (1), ciclo-(L-Pro-L-Phe) (2) e triprostatina B (3). O estruturas desses compostos foram estabelecidas com base em métodos espectroscópicos e comparação com a literatura. Os compostos 1 e 2 foram ativos contra ambas as formas de Leishmania (Leishmania) amazonensis e amastigotas intracelulares de L. (Leishmania) infantum com aproximadamente 50% de inibição do crescimento do parasita a 100 μM. Nenhum dos compostos foi considerado tóxico contra a linha celular de monócitos de leucemia humana (THP-1) a 100 μM. É o primeiro relato sobre isolamento dessas dicetopiperazinas de P. citrinum e seu potencial antileishmania contra L. (L.) infantum.pt_BR
dc.description.resumoChromatographic fractionation of the antileishmanial extract obtained from fermentation of the endophytic fungus Penicillium citrinum, isolated from leaves of Ageratum myriadenia, yielded three diketopiperazine alkaloids; cyclo(L-Pro-L-Leu) (1), cyclo-(L-Pro-L-Phe) (2) and tryprostatin B (3). The structures of these compounds were established on the basis of spectroscopic methods and comparison with the literature. Compounds 1 and 2 were active against both amastigote-like forms of Leishmania (Leishmania) amazonensis and intracelular amastigotes of L. (Leishmania) infantum with approximately 50% of parasite growth inhibition at 100 μM. None of the compounds were considered toxic against human leukemia monocyte cell line (THP-1) at 100 μM. It is the first report about isolation of these diketopiperazines from P. citrinum and their antileishmanial potential against L. (L.) infantum.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAfrican Journal of Microbiology Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMicrobiologypt_BR
dc.subjectFungipt_BR
dc.subjectBiological Productspt_BR
dc.subjectLeishmaniasispt_BR
dc.subject.otherMicrobiologiapt_BR
dc.subject.otherFungospt_BR
dc.subject.otherProdutos Biológicospt_BR
dc.subject.otherLeishmaniosept_BR
dc.titleDiketopiperazine alkaloids produced by the endophytic fungus Penicillium citrinum and evaluation of their antileishmanial activitypt_BR
dc.title.alternativeAlcalóides dicetopiperazínicos produzidos pelo endofítico fungo Penicillium citrinum e avaliação de sua atividade antileishmaniapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://academicjournals.org/journal/AJMR/article-full-text-pdf/CB8CF7D62080pt_BR
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