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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/73935
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dc.creatorCamila Ferreira Leitept_BR
dc.creatorKarine Duarte da Silvapt_BR
dc.creatorMartinho Campolina Rebello Hortapt_BR
dc.creatorMaria Cássia Ferreira de Aguiarpt_BR
dc.date.accessioned2024-08-13T21:59:51Z-
dc.date.available2024-08-13T21:59:51Z-
dc.date.issued2020-
dc.citation.volume216 Pathology research and practice :pt_BR
dc.citation.issue10pt_BR
dc.citation.spage153138pt_BR
dc.citation.epage153138pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.prp.2020.153138pt_BR
dc.identifier.issn1618-0631pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/73935-
dc.description.resumoTumor budding (TB) is a promising prognostic marker in many cancers including oral squamous cell carcinoma. The evaluation of TB in preoperative diagnostic biopsies has been proven be possible; therefore, the association of TB with other morphological features can represent an important aid in the previous treatment decision. This study aims to evaluate TB in oral squamous cell carcinoma (OSCC) biopsies, assessing its association with other morphological characteristics of the sample. A total of 56 cases of OSCC were investigated. In hematoxylin and eosin-stained slides, morphological features including histopathological grading and mode of invasion were evaluated in the deep invasive front. Moreover, immunohistochemistry was performed with anti-multi-cytokeratin antibody helping in the identification of TB, which was graded as low-intensity or no TB and high-intensity TB. Descriptive and bivariate analyses were performed, and the level of significance was set at 5%. The tongue was the most-affected site with 29 (51.7 %) tumors. The predominant mode of invasion (27-48.2 %) was by groups of neoplastic cells without clear boundaries. Of the cases investigated, 37 (66.1 %) were high-intensity TB, which was associated with the mode of invasion of the tumors (p < 0.05). All cases with the worst mode of invasion showed high-intensity TB. Preliminary results showed the potential of morphological features, such as TB and mode of invasion, evaluated in diagnostic specimens of OSCC, aiding in the treatment decision to select patients who could benefit from more-aggressive treatments.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPathology Research and Practicept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectMouthpt_BR
dc.subjectSquamous cell carcinomapt_BR
dc.subjectTumor buddingpt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherMouthpt_BR
dc.subject.otherCarcinoma, squamous cellpt_BR
dc.subject.otherPrognosispt_BR
dc.subject.otherBiopsypt_BR
dc.subject.otherAssociationpt_BR
dc.subject.otherTonguept_BR
dc.subject.otherEvaluation studypt_BR
dc.subject.otherNeoplasmspt_BR
dc.titleCan morphological features evaluated in oral cancer biopsies influence in decision-making? a preliminary studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0344033820319932?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9273-376Xpt_BR
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