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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/76034
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Campo DCValorIdioma
dc.creatorMarcela Ísis Moraispt_BR
dc.creatorMárcio de Matos Coelhopt_BR
dc.creatorRenes de Resende Machadopt_BR
dc.creatorFelipe Fernandes Rodriguespt_BR
dc.creatorSarah Olivia Alves Mendes da Costapt_BR
dc.creatorFranciele Aparecida Goulartpt_BR
dc.creatorFabio Campos Costapt_BR
dc.creatorIvo Souza Ferraz de Melopt_BR
dc.creatorPaulo Sérgio de Almeida Augustopt_BR
dc.creatorMarcela de Moura Garcia Bini Dutrapt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.date.accessioned2024-09-09T19:04:30Z-
dc.date.available2024-09-09T19:04:30Z-
dc.date.issued2018-
dc.citation.volume824pt_BR
dc.citation.spage108pt_BR
dc.citation.epage114pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ejphar.2018.02.014pt_BR
dc.identifier.issn0014-2999pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/76034-
dc.description.resumoRecently, we demonstrated that nicorandil exhibits activities in models of inflammatory and nociceptive pain. In the present study, we extended this investigation by evaluating the effects of nicorandil in models of neuropathic pain induced by paclitaxel or nerve injury in mice. Four intraperitoneal (i.p.) injections of paclitaxel (2 mg/kg.day, cumulative dose 8 mg/kg) or chronic constriction injury (CCI) of the sciatic nerve induced a long lasting mechanical allodynia. Per os (p.o.) administration of two doses of nicorandil (50, 100 and 150 mg/kg) on the 14th day after the first paclitaxel injection attenuated the mechanical allodynia. Equimolar doses of nicotinamide (86.7 mg/kg, p.o.) or nicotinic acid (87.7 mg/kg, p.o.) were devoid of effect. Mechanical allodynia induced by CCI was also attenuated by p.o. administration of two doses of nicorandil (150 mg/kg) on the 14th day after nerve injury. Nicorandil (50, 100 and 150 mg/kg, p.o.) did not affect motor activity. The antinociceptive activity of nicorandil in the model of mechanical allodynia induced by paclitaxel was partially attenuated by naltrexone (5 and 10 mg/kg, i.p.) or cyproheptadine (5 and 10 mg/kg, i.p.), but not by glibenclamide (20 and 40 mg/kg, p.o.). Concluding, nicorandil exhibits activity in experimental models of neuropathic pain when mechanical allodynia is fully established. Activation of opioidergic and serotonergic pathways mediates the antinociceptive activity of nicorandil. It is unlikely that this activity requires biotransformation to nicotinamide or nicotinic acid. Nicorandil should be further evaluated aiming to identify a new alternative in the pharmacological management of neuropathic pain.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Journal of Pharmacologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectPainpt_BR
dc.subjectNeuropathic painpt_BR
dc.subjectNicorandilpt_BR
dc.subjectPaclitaxelpt_BR
dc.subjectChronic constriction injurypt_BR
dc.subject.otherDorpt_BR
dc.subject.otherFarmacologiapt_BR
dc.subject.otherDor neuropáticapt_BR
dc.subject.otherNicorandilpt_BR
dc.subject.otherPaclitaxelpt_BR
dc.subject.otherÁcido nicotínicopt_BR
dc.subject.otherDoxorrubicinapt_BR
dc.subject.otherNicotinamidapt_BR
dc.titleNicorandil inhibits mechanical allodynia induced by paclitaxel by activating opioidergic and serotonergic mechanismspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S001429991830089Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7732-9988pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1284-1195pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2303-4452pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6572-2771pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
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