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http://hdl.handle.net/1843/76258
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DC Field | Value | Language |
---|---|---|
dc.creator | Adriana Martins Godin | pt_BR |
dc.creator | Ângelo de Fátima | pt_BR |
dc.creator | Márcio de Matos Coelho | pt_BR |
dc.creator | Renes de Resende Machado | pt_BR |
dc.creator | Débora Pereira Araújo | pt_BR |
dc.creator | Raquel Rezende Menezes | pt_BR |
dc.creator | Ana Mercy Siebra de Brito | pt_BR |
dc.creator | Ivo Souza Ferraz de Melo | pt_BR |
dc.creator | Giovanna Maria Elias Coura | pt_BR |
dc.creator | Leandro Francisco Silva Bastos | pt_BR |
dc.creator | Flávio Almeida Amaral | pt_BR |
dc.creator | Mauro Martins Teixeira | pt_BR |
dc.date.accessioned | 2024-09-10T19:53:45Z | - |
dc.date.available | 2024-09-10T19:53:45Z | - |
dc.date.issued | 2017 | - |
dc.citation.volume | 69 | pt_BR |
dc.citation.issue | 4 | pt_BR |
dc.citation.spage | 691 | pt_BR |
dc.citation.epage | 695 | pt_BR |
dc.identifier.doi | https://doi.org/10.1016/j.pharep.2017.01.033 | pt_BR |
dc.identifier.issn | 1734-1140 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/76258 | - |
dc.description.resumo | Background: Phthalimide analogs have been shown to exhibit anti-inflammatory, analgesic and immunomodulatory activities in different preclinical assays. This study aimed to investigate the potential role of 2-phthalimidethanol (PTD-OH) and 2-phthalimidethyl nitrate (PTD-NO) in a murine model of antigen-induced articular inflammation. Methods: Articular inflammation was induced by intra-articular injection of methylated bovine serum albumin (mBSA) in the knee joint of immunized male C57BL/6J mice. The animals were pre-treated with PTD-OH or PTD-NO (500 mg/kg, per os, – 1 h). Nociceptive threshold was measured using an electronic von Frey apparatus. The total number of leukocytes in the synovial cavity was determined. Concentrations of tumor necrosis factor (TNF)-α and CXCL-1 and myeloperoxidase (MPO) activity were determined in periarticular tissue. Results: Both PTD-OH and PTD-NO inhibited at similar extent the mechanical allodynia, neutrophil recruitment to the synovial cavity and periarticular tissue and TNF-α and CXCL-1 production induced by intra-articular challenge with mBSA in immunized mice. Conclusions: PTD-OH and PTD-NO exhibit a marked activity in a murine model of antigen-induced articular inflammation in immunized animals. These results reinforce the interest in the investigation of phthalimide analogs devoid of the glutarimide ring as candidates to analgesic and anti-inflammatory drugs. | pt_BR |
dc.description.sponsorship | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico | pt_BR |
dc.description.sponsorship | FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais | pt_BR |
dc.description.sponsorship | CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior | pt_BR |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS | pt_BR |
dc.publisher.department | ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA | pt_BR |
dc.publisher.department | ICB - DEPARTAMENTO DE FARMACOLOGIA | pt_BR |
dc.publisher.department | ICX - DEPARTAMENTO DE QUÍMICA | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Pharmacological Reports | pt_BR |
dc.rights | Acesso Restrito | pt_BR |
dc.subject | Phthalimide | pt_BR |
dc.subject | 2-phthalimidethyl nitrate (PTD-NO) | pt_BR |
dc.subject | Mechanical allodynia | pt_BR |
dc.subject | Cytokine | pt_BR |
dc.subject | Chemokine | pt_BR |
dc.subject | Articular inflammation | pt_BR |
dc.subject.other | Agentes antiinflamatórios | pt_BR |
dc.subject.other | Analgésicos | pt_BR |
dc.subject.other | Inflamação | pt_BR |
dc.subject.other | Agentes antineoplásicos | pt_BR |
dc.title | 2-phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammation | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://www.sciencedirect.com/science/article/abs/pii/S173411401630144X | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-1284-1195 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-4857-2302 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-1695-0612 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0002-6944-3008 | pt_BR |
dc.identifier.orcid | https://orcid.org/0000-0003-2344-5590 | pt_BR |
Appears in Collections: | Artigo de Periódico |
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