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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/76258
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dc.creatorAdriana Martins Godinpt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorMárcio de Matos Coelhopt_BR
dc.creatorRenes de Resende Machadopt_BR
dc.creatorDébora Pereira Araújopt_BR
dc.creatorRaquel Rezende Menezespt_BR
dc.creatorAna Mercy Siebra de Britopt_BR
dc.creatorIvo Souza Ferraz de Melopt_BR
dc.creatorGiovanna Maria Elias Courapt_BR
dc.creatorLeandro Francisco Silva Bastospt_BR
dc.creatorFlávio Almeida Amaralpt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.date.accessioned2024-09-10T19:53:45Z-
dc.date.available2024-09-10T19:53:45Z-
dc.date.issued2017-
dc.citation.volume69pt_BR
dc.citation.issue4pt_BR
dc.citation.spage691pt_BR
dc.citation.epage695pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.pharep.2017.01.033pt_BR
dc.identifier.issn1734-1140pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/76258-
dc.description.resumoBackground: Phthalimide analogs have been shown to exhibit anti-inflammatory, analgesic and immunomodulatory activities in different preclinical assays. This study aimed to investigate the potential role of 2-phthalimidethanol (PTD-OH) and 2-phthalimidethyl nitrate (PTD-NO) in a murine model of antigen-induced articular inflammation. Methods: Articular inflammation was induced by intra-articular injection of methylated bovine serum albumin (mBSA) in the knee joint of immunized male C57BL/6J mice. The animals were pre-treated with PTD-OH or PTD-NO (500 mg/kg, per os, – 1 h). Nociceptive threshold was measured using an electronic von Frey apparatus. The total number of leukocytes in the synovial cavity was determined. Concentrations of tumor necrosis factor (TNF)-α and CXCL-1 and myeloperoxidase (MPO) activity were determined in periarticular tissue. Results: Both PTD-OH and PTD-NO inhibited at similar extent the mechanical allodynia, neutrophil recruitment to the synovial cavity and periarticular tissue and TNF-α and CXCL-1 production induced by intra-articular challenge with mBSA in immunized mice. Conclusions: PTD-OH and PTD-NO exhibit a marked activity in a murine model of antigen-induced articular inflammation in immunized animals. These results reinforce the interest in the investigation of phthalimide analogs devoid of the glutarimide ring as candidates to analgesic and anti-inflammatory drugs.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPharmacological Reportspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectPhthalimidept_BR
dc.subject2-phthalimidethyl nitrate (PTD-NO)pt_BR
dc.subjectMechanical allodyniapt_BR
dc.subjectCytokinept_BR
dc.subjectChemokinept_BR
dc.subjectArticular inflammationpt_BR
dc.subject.otherAgentes antiinflamatóriospt_BR
dc.subject.otherAnalgésicospt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.title2-phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S173411401630144Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1284-1195pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4857-2302pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1695-0612pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6944-3008pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
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