1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/76405
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorSuvankar Daspt_BR
dc.creatorIsis Martins Figueiredopt_BR
dc.creatorEdeildo Ferreira da Silva-Júniorpt_BR
dc.creatorThiago Mendonça de Aquinopt_BR
dc.creatorJoão Xavier de Araújo-Júniorpt_BR
dc.creatorGoutam Brahmachaript_BR
dc.creatorLuzia Valentina Modolopt_BR
dc.creatorCristiane Jovelina da Silvapt_BR
dc.creatorMarina de Magalhães Silvapt_BR
dc.creatorMaria Dayanne de Araújo Dantaspt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorAna Lucia Tasca Gois Ruizpt_BR
dc.creatorCleiton Moreira da Silvapt_BR
dc.creatorJoão Ernesto de Carvalhopt_BR
dc.creatorJosué Carinhanha Caldas Santospt_BR
dc.date.accessioned2024-09-12T18:19:35Z-
dc.date.available2024-09-12T18:19:35Z-
dc.date.issued2018-
dc.citation.volume9pt_BR
dc.citation.spage51pt_BR
dc.citation.epage61pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jare.2017.10.010pt_BR
dc.identifier.issn2090-1232pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/76405-
dc.description.resumoTwenty-five piperidines were studied as potential radical scavengers and antitumor agents. Quantitative interaction of compounds with ctDNA using spectroscopic techniques was also evaluated. Our results demonstrate that the evaluated piperidines possesses different abilities to scavenge the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and the anion radical superoxide (radical dotO2−). The piperidine 19 was the most potent radical DPPH scavenger, while the most effective to radical dotO2− scavenger was piperidine 10. In general, U251, MCF7, NCI/ADR-RES, NCI-H460 and HT29 cells were least sensitive to the tested compounds and all compounds were considerably more toxic to the studied cancer cell lines than to the normal cell line HaCaT. The binding mode of the compounds and ctDNA was preferably via intercalation. In addition, these results were confirmed based on theoretical studies. Finally, a linear and exponential correlation between interaction constant (Kb) and GI50 for several human cancer cell was observed.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Advanced Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPiperidine derivativespt_BR
dc.subjectFree radical scavengingpt_BR
dc.subjectAnticancer activitypt_BR
dc.subjectDNA interactionpt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.subject.otherDNApt_BR
dc.subject.otherReações de radicais livrespt_BR
dc.subject.otherCompostos heterocíclicospt_BR
dc.titleHighly functionalized piperidines: free radical scavenging, anticancer activity, dna interaction and correlation with biological activitypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2090123217301145pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1873-5342pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1527-4501pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3187-183Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9925-6281pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8033-0434pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3239-5927pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1087-4639pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0844-8702pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9913-8971pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6901-6815pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9525-5123pt_BR
Aparece en las colecciones:Artigo de Periódico

archivos asociados a este elemento:
archivo Descripción TamañoFormato 
Highly functionalized piperidines Free radical scavenging, anticancer.pdf1.12 MBAdobe PDFVisualizar/Abrir
Mostrar registro simple del elemento Visualizar estadísticas


Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.