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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/76813
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Campo DCValorIdioma
dc.creatorTúllio Teixeira Deusdarápt_BR
dc.creatorMellanie Karoline do Carmo Félixpt_BR
dc.creatorHélio de Sousa Britopt_BR
dc.creatorEdson Wagner Silva Cangussupt_BR
dc.creatorWellington de Souza Mourapt_BR
dc.creatorBenedito Albuquerquept_BR
dc.creatorMarcos Gontijo da Silvapt_BR
dc.creatorGil Rodrigues dos Santospt_BR
dc.creatorPaula Benevides de Moraispt_BR
dc.creatorElizângela Farias da Silvapt_BR
dc.creatorYury Oliveira Chavespt_BR
dc.creatorLuís André Morais Mariubapt_BR
dc.creatorPaulo Afonso Nogueirapt_BR
dc.creatorSpartaco Astolfi-Filhopt_BR
dc.creatorEnedina Nogueira de Assunçãopt_BR
dc.creatorSabrina Epiphaniopt_BR
dc.creatorClaudio Romero Farias Marinhopt_BR
dc.creatorIgor Viana Brandipt_BR
dc.creatorKelvinson Fernandes Vianapt_BR
dc.creatorEugênio Eduardo de Oliveirapt_BR
dc.creatorAlex Sander Rodrigues Cangussupt_BR
dc.date.accessioned2024-09-23T20:03:57Z-
dc.date.available2024-09-23T20:03:57Z-
dc.date.issued2023-03-16-
dc.citation.volume11pt_BR
dc.citation.issue3pt_BR
dc.citation.spage669pt_BR
dc.identifier.doihttps://doi.org/10.3390/vaccines11030669pt_BR
dc.identifier.issn2076-393Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/76813-
dc.description.resumoAcinetobacter baumannii is a Gram-negative, immobile, aerobic nosocomial opportunistic coccobacillus that causes pneumonia, septicemia, and urinary tract infections in immunosuppressed patients. There are no commercially available alternative antimicrobials, and multi-drug resistance is an urgent concern that requires emergency measures and new therapeutic strategies. This study evaluated a multi-drug-resistant A. baumannii whole-cell vaccine, inactivated and adsorbed on an aluminum hydroxide–chitosan (mAhC) matrix, in an A. baumannii sepsis model in immunosuppressed mice by cyclophosphamide (CY). CY-treated mice were divided into immunized, non-immunized, and adjuvant-inoculated groups. Three vaccine doses were given at 0D, 14D, and 28D, followed by a lethal dose of 4.0 × 108 CFU/mL of A. baumannii. Immunized CY-treated mice underwent a significant humoral response, with the highest IgG levels and a higher survival rate (85%); this differed from the non-immunized CY-treated mice, none of whom survived (p < 0.001), and from the adjuvant group, with 45% survival (p < 0.05). Histological data revealed the evident expansion of white spleen pulp from immunized CY-treated mice, whereas, in non-immunized and adjuvanted CY-treated mice, there was more significant organ tissue damage. Our results confirmed the proof-of-concept of the immune response and vaccine protection in a sepsis model in CY-treated mice, contributing to the advancement of new alternatives for protection against A. baumannii infections.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofVaccines-
dc.rightsAcesso Abertopt_BR
dc.subject.otherBactérias anaeróbiaspt_BR
dc.subject.otherAcinetobacterpt_BR
dc.subject.otherInfecções urinariaspt_BR
dc.subject.otherImunossupressãopt_BR
dc.subject.otherCiclofosfamidapt_BR
dc.titleUsing an aluminum hydroxide–chitosan matrix increased the vaccine potential and immune response of mice against multi-drug-resistant Acinetobacter baumanniipt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.mdpi.com/2076-393X/11/3/669pt_BR
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