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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/77226
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorYuri de Freitas Regopt_BR
dc.creatorCleiton Moreira da Silvapt_BR
dc.creatorDaniel Leite da Silvapt_BR
dc.creatorJeferson Jeferson Gomespt_BR
dc.creatorAna Lucia Tasca Gois Ruizpt_BR
dc.creatorJoão Ernesto de Carvalhopt_BR
dc.creatorSergio Antonio Fernandespt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.date.accessioned2024-10-04T16:31:34Z-
dc.date.available2024-10-04T16:31:34Z-
dc.date.issued2019-
dc.citation.volume12pt_BR
dc.citation.issue8pt_BR
dc.citation.spage4065pt_BR
dc.citation.epage4073pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.arabjc.2016.04.007pt_BR
dc.identifier.issn1878-5379pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/77226-
dc.description.resumoFourteen phthalazine-triones bearing different substituents at C-4 position were synthesized through multicomponent reactions (MCR) by using phthalhydrazide, dimedone and diferent aldehydes as starting materials, p-sulfonic acid calix[4]arene as catalyst and ethyl lactate as solvent under microwave irradiation. Compounds 7–16 were obtained in excellent to moderate yields (94–51%) in only 10 min of reaction using this methodology. The antiproliferative activity against cancer cells was disclosed, for the first time, for synthesized compounds. The capacity of all compounds to inhibit cancer cells growth was dependent on the histological origin of cells. Compound 20 was active against more than one strain.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArabian Journal of Chemistrypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCatalysispt_BR
dc.subjectGreen chemistrypt_BR
dc.subjectMicrowave assisted synthesispt_BR
dc.subjectAntiproliferative activitypt_BR
dc.subjectp-Sulfonic acid calix[4]arenept_BR
dc.subject.otherCompostos heterocíclicospt_BR
dc.subject.otherCatalisept_BR
dc.subject.otherMicroondaspt_BR
dc.subject.otherCalixarenospt_BR
dc.subject.otherAgentes antineoplasicospt_BR
dc.titlePhthalazine-triones: calix[4]arene-assisted synthesis using green solvents and their anticancer activities against human cancer cellspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1878535216300314pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4660-6852pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9913-8971pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3468-8478pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4219-1437pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0844-8702pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6901-6815pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3054-3316pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
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