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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/77309
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Campo DCValorIdioma
dc.creatorCarla Ribeiro Álvares Batistapt_BR
dc.creatorDébora Pereira Araújopt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorRenes de Resende Machadopt_BR
dc.creatorMárcio de Matos Coelhopt_BR
dc.creatorAdriana Martins Godinpt_BR
dc.creatorIvo Souza Ferraz de Melopt_BR
dc.creatorGiovanna Maria Elias Courapt_BR
dc.creatorTamires Cardoso Matsuipt_BR
dc.creatorMarcela de Moura Garcia Bini Dutrapt_BR
dc.creatorAna Mercy Siebra de Britopt_BR
dc.creatorWagner Gonçalves Canhestropt_BR
dc.creatorRicardo José Alvespt_BR
dc.date.accessioned2024-10-08T18:21:27Z-
dc.date.available2024-10-08T18:21:27Z-
dc.date.issued2019-
dc.citation.volume71pt_BR
dc.citation.issue6pt_BR
dc.citation.spage1177pt_BR
dc.citation.epage1183pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.pharep.2019.08.001pt_BR
dc.identifier.issn1734-1140pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/77309-
dc.description.resumoBackground: Phthalimide analogues devoid of the glutarimide moiety exhibit multiple biological activities, thus making them candidates for the treatment of patients with different diseases, including those with inflammatory and painful disorders. In the present study, the activities of five phthalimide analogues devoid of the glutarimide moiety (N-hydroxyphthalimide, N-hydroxymethylphthalimide, N-3-hydroxypropylphthalimide, N-carboxy-3-methylphthalimide, N-carboxymethyl-3-nitrophthalimide) were evaluated in experimental models of acute and chronic inflammatory and neuropathic pain. Methods: The phthalimide analogues were administered per os (po) in Swiss mice or Wistar rats. Nociceptive response induced by formaldehyde and mechanical allodynia induced by chronic constriction injury (CCI) of the sciatic nerve or intraplantar (ipl) injection of complete Freund’s adjuvant (CFA) were used as experimental models of pain. Results: N-carboxymethyl-3-nitrophthalimide (700 mg/kg, -1 h) inhibited the second phase of the nociceptive response induced by the intraplantar injection of formaldehyde in mice. N-3-hidroxypropylphthalimide (546 mg/kg, -1 h) inhibited both phases of the nociceptive response induced by formaldehyde. Treatment of rats with N-carboxymethyl-3-nitrophthalimide (700 mg/kg) or N-3-hydroxypropylphthalimide (546 mg/kg) inhibited the mechanical allodynia induced by CCI of the sciatic nerve or ipl injection of CFA in rats. Intraperitoneal administration of the opioid antagonist naltrexone (10 mg/kg, -1.5 h) attenuated the antinociceptive activity of N-carboxymethyl-3-nitrophthalimide (700 mg/kg) in the model of nociceptive response induced by formaldehyde. Conclusions: N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide, two phthalimide analogues devoid of the glutarimide moiety, exhibited activities in different experimental models of pain, including models of chronic inflammatory and neuropathic pain.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPharmacological Reportspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectPhatalimide analoguespt_BR
dc.subjectAntiinflammatorypt_BR
dc.subjectNeuropathic painpt_BR
dc.subject.otherFarmacologiapt_BR
dc.subject.otherAgentes antiinflamatoriospt_BR
dc.subject.otherDorpt_BR
dc.titleThe phthalimide analogues n-3-hydroxypropylphthalimide and n-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic painpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S1734114019303238pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5826-4330pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1284-1195pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4857-2302pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6572-2771pt_BR
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