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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/77990
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Campo DCValorIdioma
dc.creatorWellington Alves de Barrospt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorCamila da Silva Nunespt_BR
dc.creatorJuliana Alves da Costa Ribeiro Souzapt_BR
dc.creatorIgor José dos Santos Nascimentopt_BR
dc.creatorIsis Martins Figueiredopt_BR
dc.creatorThiago Mendonça de Aquinopt_BR
dc.creatorLeonardo Vieirapt_BR
dc.creatorDavi Felipe Fariaspt_BR
dc.creatorJosué Carinhanha Caldas Santospt_BR
dc.date.accessioned2024-11-12T18:49:52Z-
dc.date.available2024-11-12T18:49:52Z-
dc.date.issued2021-
dc.citation.volume2pt_BR
dc.citation.spage386pt_BR
dc.citation.epage398pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.crtox.2021.11.002pt_BR
dc.identifier.issn2666-027Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/77990-
dc.description.resumoToxicological effects of 25H-NBOMe and 25H-NBOH recreational drugs on zebrafish embryos and larvae at the end of 96 h exposure period were demonstrated. 25H-NBOH and 25H-NBOMe caused high embryo mortality at 80 and 100 µg mL−1, respectively. According to the decrease in the concentration tested, lethality decreased while non-lethal effects were predominant up to 10 and 50 µg mL−1 of 25H-NBOH and 25H-NBOMe, respectively, including spine malformation, egg hatching delay, body malformation, otolith malformation, pericardial edema, and blood clotting. We can disclose that these drugs have an affinity for DNA in vitro using biophysical spectroscopic assays and molecular modeling methods. The experiments demonstrated that 25H-NBOH and 25H-NBOMe bind to the unclassical major groove of ctDNA with a binding constant of 27.00 × 104 M−1 and 5.27 × 104 M−1, respectively. Furthermore, these interactions lead to conformational changes in the DNA structure. Therefore, the results observed in the zebrafish embryos and DNA may be correlated.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCurrent Research in Toxicologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPhenethylaminespt_BR
dc.subjectIlicit Drugspt_BR
dc.subjectDNA interactionpt_BR
dc.subjectZebra fishpt_BR
dc.subjectNBOHspt_BR
dc.subjectNBOMespt_BR
dc.subject.otherDrogas - Toxicologiapt_BR
dc.subject.otherFenetilaminapt_BR
dc.subject.otherDrogas - Uso recreativopt_BR
dc.subject.otherDNApt_BR
dc.subject.otherAlucinógenospt_BR
dc.subject.otherEspectroscopia de fluorescênciapt_BR
dc.subject.otherEspectroscopia de ressonância nuclearpt_BR
dc.titleThe new psychoactive substances 25H-NBOMe and 25H-NBOH induce abnormal development in the zebrafish embryo and interact in the DNA major groovept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2666027X21000402?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3479-0720pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2664-4336pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1873-5342pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9138-8466pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9525-5123pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5438-1919pt_BR
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