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Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/78301
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Campo DCValorIdioma
dc.creatorGeraldo Magela Fernandespt_BR
dc.creatorLizandra Moura Paravidine Sasakipt_BR
dc.creatorGabriela Profírio Jardim-Santospt_BR
dc.creatorHeidi Luise Schultept_BR
dc.creatorFelipe Mottapt_BR
dc.creatorÂngelo Pereira da Silvapt_BR
dc.creatorAleida Oliveira de Carvalhopt_BR
dc.creatorYacara Ribeiro Pereirapt_BR
dc.creatorCaroline de Oliveira Alvespt_BR
dc.creatorOtávio de Toledo Nóbregapt_BR
dc.creatorDavid Alves de Araújo Júniorpt_BR
dc.creatorLizandra Moura Paravidine Sasakipt_BR
dc.creatorDayde Lane Mendonça-Silvapt_BR
dc.creatorKarina Nascimento Costapt_BR
dc.creatorMaria Eduarda Canellas de Castropt_BR
dc.creatorLucas Lauandpt_BR
dc.creatorRodrigo de Resende Nerypt_BR
dc.creatorRosana Tristãopt_BR
dc.creatorPatricia Shu Kurizkypt_BR
dc.creatorOtávio de Toledo Nóbregapt_BR
dc.creatorLaila Salmen Espindolapt_BR
dc.creatorLuiz Cláudio Gonçalves de Castropt_BR
dc.creatorPatrícia Nessralla Alpoimpt_BR
dc.creatorLara Carvalho Godoipt_BR
dc.creatorLuci Maria Sant Ana Dussept_BR
dc.creatorJordana Grazziela Alves Coelho-Dos-Reispt_BR
dc.creatorLaurence Rodrigues do Amaralpt_BR
dc.creatorMatheus de Souza Gomespt_BR
dc.creatorPedro Luiz Lima Bertarinipt_BR
dc.creatorJoaquim Pedro Brito-de-Sousapt_BR
dc.creatorIsmael Artur da Costa-Rochapt_BR
dc.creatorAna Carolina Campi-Azevedopt_BR
dc.creatorVanessa Peruhype-Magalhãespt_BR
dc.creatorAndrea Teixeira-Carvalhopt_BR
dc.creatorAlberto Moreno Zaconetapt_BR
dc.creatorAlexandre Anderson de Sousa Munhoz Soarespt_BR
dc.creatorValéria Valimpt_BR
dc.creatorCiro Martins Gomespt_BR
dc.creatorCleandro Pires de Albuquerquept_BR
dc.creatorOlindo Assis Martins-Filhopt_BR
dc.creatorLicia Maria Henrique da Motapt_BR
dc.date.accessioned2024-11-26T22:43:08Z-
dc.date.available2024-11-26T22:43:08Z-
dc.date.issued2023-04-11-
dc.citation.volume14pt_BR
dc.citation.spage1pt_BR
dc.citation.epage15pt_BR
dc.identifier.doi10.3389/fimmu.2023.1176898pt_BR
dc.identifier.issn1664-3224pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/78301-
dc.description.resumoAbstract Introduction: SARS-CoV-2 infection during pregnancy can induce changes in the maternal immune response, with effects on pregnancy outcome and offspring. This is a cross-sectional observational study designed to characterize the immunological status of pregnant women with convalescent COVID-19 at distinct pregnancy trimesters. The study focused on providing a clear snapshot of the interplay among serum soluble mediators. Methods: A sample of 141 pregnant women from all prenatal periods (1st, 2nd and 3rd trimesters) comprised patients with convalescent SARS-CoV-2 infection at 3-20 weeks after symptoms onset (COVID, n=89) and a control group of pre-pandemic non-infected pregnant women (HC, n=52). Chemokine, pro-inflammatory/regulatory cytokine and growth factor levels were quantified by a high-throughput microbeads array. Results: In the HC group, most serum soluble mediators progressively decreased towards the 2nd and 3rd trimesters of pregnancy, while higher chemokine, cytokine and growth factor levels were observed in the COVID patient group. Serum soluble mediator signatures and heatmap analysis pointed out that the major increase observed in the COVID group related to pro-inflammatory cytokines (IL-6, TNF-α, IL-12, IFN-γ and IL-17). A larger set of biomarkers displayed an increased COVID/HC ratio towards the 2nd (3x increase) and the 3rd (3x to 15x increase) trimesters. Integrative network analysis demonstrated that HC pregnancy evolves with decreasing connectivity between pairs of serum soluble mediators towards the 3rd trimester. Although the COVID group exhibited a similar profile, the number of connections was remarkably lower throughout the pregnancy. Meanwhile, IL-1Ra, IL-10 and GM-CSF presented a preserved number of correlations (≥5 strong correlations in HC and COVID), IL-17, FGF-basic and VEGF lost connectivity throughout the pregnancy. IL-6 and CXCL8 were included in a set of acquired attributes, named COVID-selective (≥5 strong correlations in COVID and <5 in HC) observed at the 3rd pregnancy trimester. Discussion and conclusion: From an overall perspective, a pronounced increase in serum levels of soluble mediators with decreased network interplay between them demonstrated an imbalanced immune response in convalescent COVID-19 infection during pregnancy that may contribute to the management of, or indeed recovery from, late complications in the post-symptomatic phase of the SARS-CoV-2 infection in pregnant women.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Immunology-
dc.rightsAcesso Abertopt_BR
dc.subjectQuimiocinaspt_BR
dc.subjectCitocinaspt_BR
dc.subjectCovid-19pt_BR
dc.subjectGravidezpt_BR
dc.subjectFator de crescimentopt_BR
dc.subject.otherCovi-19pt_BR
dc.subject.otherGravidezpt_BR
dc.titlePanoramic snapshot of serum soluble mediator interplay in pregnant women with convalescent covid-19: an exploratory studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1176898/fullpt_BR
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