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Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/78303
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Campo DCValorIdioma
dc.creatorAna Cristina dos Santos Lopespt_BR
dc.creatorLetícia Parreira Nunes Sousapt_BR
dc.creatorRívia Mara Morais e Silvapt_BR
dc.creatorAna Cristina Simões e Silvapt_BR
dc.creatorLuci Maria Sant`ana Dussept_BR
dc.creatorPatrícia Nessralla Alpoimpt_BR
dc.date.accessioned2024-11-26T23:26:23Z-
dc.date.available2024-11-26T23:26:23Z-
dc.date.issued2022-08-31-
dc.citation.volume100pt_BR
dc.citation.issue9pt_BR
dc.citation.spage926pt_BR
dc.citation.epage936pt_BR
dc.identifier.doi10.1139/cjpp-2021-0714pt_BR
dc.identifier.issn0008-4212pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/78303-
dc.description.resumoChronic kidney disease (CKD) can be defined as the progressive loss of renal function, characterized by a decreased glomerular filtration rate (GFR). The etiology of CKD in childhood is mainly associated with congenital anomalies of the kidneys and urinary tract (CAKUT) and with glomerular diseases. The goal of this study was to investigate the hemostasis and oxidative stress in pediatric CKD of different etiologies. Fifty-four CKD children and adolescents and 52 controls were enrolled in this study. The evaluation of hemostasis was carried out by determination of D-dimer (D-Di) and plasminogen activator inhibitor (PAI-1) plasma levels, while oxidative stress was evaluated by thiobarbituric acid reactive substance (TBARS) levels, protein carbonyl content, plasma antioxidant capacity (MTT), and ascorbate. The D-Di was increased in CAKUT stage 3 or 4 patients compared with those with glomerular disease. PAI-1 was increased in patients with glomerular disease compared with CAKUT. Carbonyl protein content was higher in the control group compared with glomerular disease stage 3 or 4 patients. Our findings showed that the reduction in GFR is associated with a state of hypercoagulability. The analysis of integrated networks showed an expansion of connections among hemostatic and oxidative stress markers in CKD children and adolescents compared with controls.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology-
dc.rightsAcesso Restritopt_BR
dc.subjectDoença renal crônicapt_BR
dc.subjectHemostasiapt_BR
dc.subjectEstresse oxidativopt_BR
dc.subjectCriançapt_BR
dc.subjectAdolescentespt_BR
dc.subject.otherMedicinapt_BR
dc.subject.otherDoença renal crônicapt_BR
dc.titleHemostasis and oxidative stress in chronic kidney disease in children and adolescentspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://cdnsciencepub.com/doi/full/10.1139/cjpp-2021-0714pt_BR
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