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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/78678
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Campo DCValorIdioma
dc.creatorMaria Carolina Feres de Lima Rochagamapt_BR
dc.creatorEleonora Druve Tavares Fagundespt_BR
dc.creatorThaís Costa Nascentes Queirozpt_BR
dc.creatorAdriana Teixeira Rodriguespt_BR
dc.creatorLuiza Caroline Vieirapt_BR
dc.creatorAlexandre Rodrigues Ferreirapt_BR
dc.date.accessioned2024-12-13T19:32:42Z-
dc.date.available2024-12-13T19:32:42Z-
dc.date.issued2023-
dc.citation.volume60pt_BR
dc.citation.issue2pt_BR
dc.citation.spage247pt_BR
dc.citation.epage256pt_BR
dc.identifier.doi10.1590/s0004-2803.202302023-37pt_BR
dc.identifier.issn00042803pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/78678-
dc.description.resumoMost data on the natural history of portal hypertension come from studies in adults. The morbidity rate of upper gastrointestinal bleeding (UGIB) in children with portal hypertension has not been systematically characterized. Objective – To describe the morbidity and mortality of UGIB in pediatric patients with portal hypertension and identify predictive factors for the occurrence of its main complications.Methods – This retrospective study included pediatric patients with cir rhotic portal hypertension or with extrahepatic portal vein obstruction (EHPVO). Mortality and UGIB complications within a period of up to 6 weeks of the bleeding were investigated. To determine the predictive factors of morbidity, a multivariate analysis was performed using logistic regression; all results were considered significant at P<0.05. Results – A total of 86 patients (51.2% with EHPVO and 48.8% with cirrhosis) had 174 bleeding events. Ascites was the most common complication (43.1% of all cases), being more prevalent in patients with cirrhosis (P<0.001). Cirrhosis was a predictor of the occurrence of any morbidity (OR 20.3). The need for blood transfusion was predictor of at least one complica tion (OR 5.8), ascites (OR 7.2) and infections (OR 3.8) in the general group and at least one complication (OR 11.3) and ascites (OR 5.8) in cirrhotic patients. The need for expansion was a predictor of any morbidity (OR 4.6) and infections (OR 3.9) in the general group, in addition to being predictor of infection in cirrhotic patients (OR 5.4). There were no deaths from UGIB in the six weeks post-bleeding. Conclusion – The study showed the relevance of morbidity after UGIB in pediatric patients with portal hypertension, especially in those with cirrhosis. The patients with hemodynamic instability requiring blood transfusion or expansion on admission are at increased risk of complications related to upper gastrointestinal bleeding and should be closely monitored.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArquivos de Gastroenterologia-
dc.rightsAcesso Abertopt_BR
dc.subjectHypertension, Portalpt_BR
dc.subjectAcute variceal bleedingpt_BR
dc.subjectEsophageal and Gastric Varicespt_BR
dc.subjectmorbiditypt_BR
dc.subjectChildrenpt_BR
dc.subject.otherHypertension, Portalpt_BR
dc.subject.otherEsophageal and Gastric Varicespt_BR
dc.subject.otherMorbiditypt_BR
dc.subject.otherChildrenpt_BR
dc.titlePredictive factors of morbidity associated with esophageal variceal bleeding in children with portal hypertensionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://doi.org/10.1590/S0004-2803.202302023-37pt_BR
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