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Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/79382
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Campo DCValorIdioma
dc.creatorAlice Maria de Magalhães Ornelaspt_BR
dc.creatorCaroline Xavier-de-Carvalhopt_BR
dc.creatorLucia Elena Alvarado-Arnezpt_BR
dc.creatorMarcelo Ribeiro-Alvespt_BR
dc.creatorÁtila Duque Rossipt_BR
dc.creatorAmilcar Tanuript_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorMilton Ozório Moraespt_BR
dc.creatorCynthia Chester Cardosopt_BR
dc.date.accessioned2025-01-21T21:08:26Z-
dc.date.available2025-01-21T21:08:26Z-
dc.date.issued2019-
dc.citation.volume114pt_BR
dc.citation.spage1pt_BR
dc.citation.epage9pt_BR
dc.identifier.issn0074-0276pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/79382-
dc.description.resumoBACKGROUND Dengue is an arthropod-borne viral disease with a majority of asymptomatic individuals and clinical manifestations varying from mild fever to severe and potentially lethal forms. An increasing number of genetic studies have outlined the association between host genetic variations and dengue severity. Genes associated to viral recognition and entry, as well as those encoding mediators of the immune response against infection are strong candidates for association studies. OBJECTIVES The aim of this study was to investigate the association between MBL2, CLEC5A, ITGB3 and CCR5 genes and dengue severity in children. METHODS A matched case-control study was conducted and 19 single nucleotide polymorphisms (SNPs) were investigated. FINDINGS No associations were observed in single SNP analysis. However, when MBL2 SNPs were combined in haplotypes, the allele rs7095891G/rs1800450C/ rs1800451C/rs4935047A/rs930509G/rs2120131G/rs2099902C was significantly associated to risk of severe dengue under α = 0.05 (aOR = 4.02; p = 0.02). A second haplotype carrying rs4935047G and rs7095891G alleles was also associated to risk (aOR = 1.91; p = 0.04). MAIN CONCLUSIONS This is the first study to demonstrate the association between MBL2 haplotypes and dengue severity in Brazilians including adjustment for genetic ancestry. These results reinforce the role of mannose binding lectin in immune response to DENV.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMemórias do Instituto Oswaldo Cruzpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDenguept_BR
dc.subjectPolymorphismspt_BR
dc.subjectMBL2pt_BR
dc.subjectCCR5pt_BR
dc.subjectITGB3pt_BR
dc.subjectCLEC5Apt_BR
dc.subject.otherGenéticapt_BR
dc.subject.otherVírus da denguept_BR
dc.subject.otherPesquisa imunológicapt_BR
dc.titleAssociation between MBL2 haplotypes and dengue severity in children from Rio de Janeiro, Brazilpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.arca.fiocruz.br/handle/icict/33446pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3537-6361pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8663-3364pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6235-8807pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2653-0037pt_BR
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