1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/79414
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorVictor Emmanuel Viana Geddespt_BR
dc.creatorEurico de Arruda Netopt_BR
dc.creatorAmilcar Tanuript_BR
dc.creatorRenan Pedra Souzapt_BR
dc.creatorIranaia Assunção-Mirandapt_BR
dc.creatorSoniza Vieira Alves-Leonpt_BR
dc.creatorLuciana Ferreira Romãopt_BR
dc.creatorJorge Paes Barreto Marcondes de Souzapt_BR
dc.creatorAna Tereza Ribeiro de Vasconcelospt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorOtávio José Bernardes Brustolinipt_BR
dc.creatorLiliane Tavares de Faria Cavalcantept_BR
dc.creatorFilipe Romero Rebello Moreirapt_BR
dc.creatorFernando Luz de Castropt_BR
dc.creatorAna Paula de Campos Guimarãespt_BR
dc.creatorAlexandra Lehmkuhl Gerberpt_BR
dc.creatorCamila Menezes Figueiredopt_BR
dc.creatorLuan Pereira Dinizpt_BR
dc.date.accessioned2025-01-22T21:02:06Z-
dc.date.available2025-01-22T21:02:06Z-
dc.date.issued2021-03-15-
dc.citation.volume11pt_BR
dc.citation.spage1pt_BR
dc.citation.epage17pt_BR
dc.identifier.doihttps://doi.org/10.3389/fcimb.2021.641261pt_BR
dc.identifier.issn2235-2988pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/79414-
dc.description.resumoArboviruses pose a major threat throughout the world and represent a great burden in tropical countries of South America. Although generally associated with moderate febrile illness, in more severe cases they can lead to neurological outcomes, such as encephalitis, Guillain-Barré syndrome, and Congenital Syndromes. In this context astrocytes play a central role in production of inflammatory cytokines, regulation of extracellular matrix, and control of glutamate driven neurotoxicity in the central nervous system. Here, we presented a comprehensive genome-wide transcriptome analysis of human primary astrocytes infected with Chikungunya, Mayaro, Oropouche, or Zika viruses. Analyses of differentially expressed genes (DEGs), pathway enrichment, and interactomes have shown that Alphaviruses up-regulated genes related to elastic fiber formation and N-glycosylation of glycoproteins, with down-regulation of cell cycle and DNA stability and chromosome maintenance genes. In contrast, Oropouche virus up-regulated cell cycle and DNA maintenance and condensation pathways while down-regulated extracellular matrix, collagen metabolism, glutamate and ion transporters pathways. Zika virus infection only up-regulated eukaryotic translation machinery while down-regulated interferon pathways. Reactome and integration analysis revealed a common signature in down-regulation of innate immune response, antiviral response, and inflammatory cytokines associated to interferon pathway for all arboviruses tested. Validation of interferon stimulated genes by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) corroborated our transcriptome findings. Altogether, our results showed a co-evolution in the mechanisms involved in the escape of arboviruses to antiviral immune response mediated by the interferon (IFN) pathway.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE ZOOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Cellular and Infection Microbiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectChikungunyapt_BR
dc.subjectMayaropt_BR
dc.subjectOropouchept_BR
dc.subjectZikapt_BR
dc.subjectInnate immunitypt_BR
dc.subjectAstrocytespt_BR
dc.subject.otherVírus da Zikapt_BR
dc.subject.otherChikungunyapt_BR
dc.subject.otherImunidadept_BR
dc.subject.otherArbovíruspt_BR
dc.titleCommon dysregulation of innate immunity pathways in human primary astrocytes infected with chikungunya, mayaro, oropouche, and zika virusespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.641261/fullpt_BR
Aparece en las colecciones:Artigo de Periódico

archivos asociados a este elemento:
archivo Descripción TamañoFormato 
Common Dysregulation of Innate Immunity Pathways in Human Primary Astrocytes Infected With Chikungunya, Mayaro, Oropouche, and Zika Viruses.pdf1.68 MBAdobe PDFVisualizar/Abrir
Mostrar registro simple del elemento Visualizar estadísticas


Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.