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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/79445
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Campo DCValorIdioma
dc.creatorFilipe Romero Rebello Moreirapt_BR
dc.creatorRodrigo Decembrino Vargas Brasilpt_BR
dc.creatorDarlan da Silva Cândidopt_BR
dc.creatorAlice Laschuk Herlingerpt_BR
dc.creatorMarisa de Oliveira Ribeiropt_BR
dc.creatorMonica Barcellos Arrudapt_BR
dc.creatorPatricia Alvarezpt_BR
dc.creatorMarcelo Calado de Paula Tôrrespt_BR
dc.creatorIlaria Dorigattipt_BR
dc.creatorOliver Bradypt_BR
dc.creatorCarolina Moreira Volochpt_BR
dc.creatorMariane Talon de Menezespt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorClarisse Salgado-benvindopt_BR
dc.creatorCharles Whittakerpt_BR
dc.creatorVictoria Coxpt_BR
dc.creatorNilani Chandradevapt_BR
dc.creatorHury Hellen Souza de Paulapt_BR
dc.creatorAndré Frederico Martinspt_BR
dc.creatorRaphael Rangel das Chagaspt_BR
dc.date.accessioned2025-01-23T21:20:32Z-
dc.date.available2025-01-23T21:20:32Z-
dc.date.issued2023-09-28-
dc.citation.volume17pt_BR
dc.citation.issue9pt_BR
dc.citation.spage1pt_BR
dc.citation.epage19pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0011536pt_BR
dc.identifier.issn1935-2735pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/79445-
dc.description.resumoSince 2014, Brazil has experienced an unprecedented epidemic caused by chikungunya virus (CHIKV), with several waves of East-Central-South-African (ECSA) lineage transmission reported across the country. In 2018, Rio de Janeiro state, the third most populous state in Brazil, reported 41% of all chikungunya cases in the country. Here we use evolutionary and epidemiological analysis to estimate the timescale of CHIKV-ECSA-American lineage and its epidemiological patterns in Rio de Janeiro. We show that the CHIKV-ECSA outbreak in Rio de Janeiro derived from two distinct clades introduced from the Northeast region in mid-2015 (clade RJ1, n = 63/67 genomes from Rio de Janeiro) and mid-2017 (clade RJ2, n = 4/67). We detected evidence for positive selection in non-structural proteins linked with viral replication in the RJ1 clade (clade-defining: nsP4-A481D) and the RJ2 clade (nsP1-D531G). Finally, we estimate the CHIKV-ECSA’s basic reproduction number (R0) to be between 1.2 to 1.6 and show that its instantaneous reproduction number (Rt) displays a strong seasonal pattern with peaks in transmission coinciding with periods of high Aedes aegypti transmission potential. Our results highlight the need for continued genomic and epidemiological surveillance of CHIKV in Brazil, particularly during periods of high ecological suitability, and show that selective pressures underline the emergence and evolution of the large urban CHIKV-ECSA outbreak in Rio de Janeiro.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPLOS Neglected Tropical Diseasespt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherChikungunyapt_BR
dc.subject.otherEpidemiologiapt_BR
dc.subject.otherGéneticapt_BR
dc.subject.otherBiologiapt_BR
dc.subject.otherVíruspt_BR
dc.titleEpidemiological and genomic investigation of chikungunya virus in Rio de Janeiro state, Brazil, between 2015 and 2018pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0011536pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7162-5070pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5180-3717pt_BR
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