Potencial de interação medicamentosa entre anti-inflamatórios não esteroidais e varfarina: um estudo transversal relacionado à segurança do paciente

Abstract

This study aimed to investigate the frequency, and social and demographic factors associated with potential drug-drug interaction (PDDI) between warfarin and non- steroidal anti-inflammatory drugs (NSAIDs) prescribed by dentists in the state of Minas Gerais (MG), Southeast Brazil. A secondary data analysis of a cross-sectional study was conducted using data from the Integrated Pharmaceutical Care Management System (Sigaf) in MG, Brazil, from January to December 2021. IBM SPSS, version 26.0, and Hierarchical Linear and Nonlinear Modelling, version 7.0, were used for data analysis. Poisson Regression was used to estimate the prevalence ratio of potential drug interactions between individual variables. Data were collected and analyzed from individuals residing in 678 out of 853 municipalities in MG (79.5%). In 2021, 14,474 individuals received warfarin and, among those, 122 received a dental prescription for NSAID. The PDDI occurred in 60 patients. Individuals up to 62 years of age showed a higher prevalence of PDDI (p<0.001). The frequency of PIM among warfarin users was low in 2021. However, among those who received warfarin and dental prescriptions for NSAIDs, the occurrence of PIM was significant. Furthermore, patient age was found to be an influential factor in PIM.