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  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/79584
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorTaniris Cafiero Bragapt_BR
dc.creatorFelipe Terra Martinspt_BR
dc.creatorIsis Martins Figueiredopt_BR
dc.creatorThiago Mendonça de Aquinopt_BR
dc.creatorCleiton Moreira da Silvapt_BR
dc.creatorBhagirath Mandalpt_BR
dc.creatorGoutam Brahmachaript_BR
dc.creatorJosué Carinhanha Caldas Santospt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorMarina de Magalhães Silvapt_BR
dc.creatorEduarda O.O. Nascimentopt_BR
dc.creatorEdjan Carlos Dantas da Silvapt_BR
dc.creatorYuri de Freitas Regopt_BR
dc.creatorMullicka Mandalpt_BR
dc.creatorZaqueu Alves de Souzapt_BR
dc.creatorAna Lúcia Tasca Góis Ruizpt_BR
dc.creatorJoão Ernesto de Carvalhopt_BR
dc.date.accessioned2025-01-31T19:27:17Z-
dc.date.available2025-01-31T19:27:17Z-
dc.date.issued2022-
dc.citation.volume4pt_BR
dc.citation.spage100030pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ejmcr.2022.100030pt_BR
dc.identifier.issn2772-4174pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/79584-
dc.description.resumoTwenty chromenes were synthesized with good to excellent yields (70–96%). From the series of chromenes herein tested, compounds 14, 12, 15, 16, 17, 18, and 20 were the most potent throughout the cancer human cell lines tested. In general, the para-position electron-withdrawing substituents on the phenyl ring are favored towards potency and selectivity for cancer cells. Biophysical studies were performed with eight chromene derivatives (13-20) and ctDNA to evaluate possible biological targets. The molecular fluorescence verified that compound 16 presented a higher binding constant (Kb) with the ctDNA, agreeing with in vitro biological results and that evaluated chromenes derivatives interact preferentially via intercalation. Finally, an inverse linear correlation (logKb vs. GI50) was observed for six human carcinogenic cell lines; hence, the mechanism of action of these compounds may be related to DNA interaction.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Journal of Medicinal Chemistry Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectChromenept_BR
dc.subjectAntiproliferative activitypt_BR
dc.subjectBioanalytical correlationpt_BR
dc.subjectDNA interactionpt_BR
dc.subjectIntercalationpt_BR
dc.subject.otherCompostos heterocíclicospt_BR
dc.subject.otherDNApt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.subject.otherRaios X - Difraçãopt_BR
dc.subject.otherFluorescênciapt_BR
dc.subject.otherEspectrometria de ultra violetapt_BR
dc.titleSynthesis, anticancer activities and experimental-theoretical dna interaction studies of 2-amino-4-phenyl-4h-benzo[h]chromene-3-carbonitrilept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2772417422000024?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4032-0100pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9004-0927pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1873-5342pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9138-8466pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9913-8971pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3491-2249pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9925-6281pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9525-5123pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1087-4639pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4660-6852pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0698-5341pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0844-8702pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6901-6815pt_BR
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