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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/79738
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Campo DCValorIdioma
dc.creatorMaria de Lourdes Rabelo Guimarãespt_BR
dc.creatorPedro Guimarães de Azevedopt_BR
dc.creatorRenan Pedra de Souzapt_BR
dc.creatorEitan Friedmanpt_BR
dc.creatorLuíz Armando Cunha de Marcopt_BR
dc.creatorLuciana Bastos Rodriguespt_BR
dc.date.accessioned2025-02-06T21:03:19Z-
dc.date.available2025-02-06T21:03:19Z-
dc.date.issued2023-10-10-
dc.citation.volume43pt_BR
dc.citation.issue6pt_BR
dc.citation.spage409pt_BR
dc.citation.epage416pt_BR
dc.identifier.doi10.14639/0392-100X-N2532pt_BR
dc.identifier.issn1827-675Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/79738-
dc.description.resumoPurpose. To evaluate the correlation between several presumed candidate genes for obstructive sleep apnoea (OSA) and clinical OSA phenotypes and propose a predictive comprehensive model for diagnosis of OSA. Methods. This case-control study compared polysomnographic patterns, clinical data, morbidities, dental factors and genetic data for polymorphisms in PER3, BDNF, NRXN3, APOE, HCRTR2, MC4R between confirmed OSA cases and ethnically matched clinically unaffected controls. A logistic regression model was developed to predict OSA using the combined data. Results. The cohort consisted of 161 OSA cases and 81 controls. Mean age of cases was 53.5 ± 14.0 years, mostly males (57%) and mean body mass index (BMI) of 27.5 ± 4.3 kg/ m2. None of the genotyped markers showed a statistically significant association with OSA after adjusting for age and BMI. A predictive algorithm included the variables gender, age, snoring, hypertension, mouth breathing and number of T alleles of PER3 (rs228729) presenting 76.5% specificity and 71.6% sensitivity. Conclusions. No genetic variant tested showed a statistically significant association with OSA phenotype. Logistic regression analysis resulted in a predictive model for diagnosing OSA that, if validated by larger prospective studies, could be applied clinically to allow risk stratification for OSA.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMEDICINA - FACULDADE DE MEDICINApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofActa Otorhinolaryngol Italicapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectObstructive sleep apneapt_BR
dc.subjectGenetic polymorphismspt_BR
dc.subjectPhenotypept_BR
dc.subjectAlgorithmspt_BR
dc.subjectCase-control studiespt_BR
dc.subject.otherGenéticapt_BR
dc.subject.otherSíndromes da apnéia do sonopt_BR
dc.subject.otherAlgorítmos genéticospt_BR
dc.titleEvaluation of clinical and genetic factors in obstructive sleep apnoeapt_BR
dc.title.alternativeValutazione dei fattori clinici e genetici nella sindrome da apnee ostruttive del sonnopt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://old.actaitalica.it/article/view/2532pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5271-5548pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9352-1224pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9479-4432pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6745-1733pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1161-8936pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9053-7201pt_BR
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