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Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/79773
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Campo DCValorIdioma
dc.creatorLudmila Karen dos Santos Silvapt_BR
dc.creatorAna Cláudia dos Santos Pereira Andradept_BR
dc.creatorFábio Pio Dornaspt_BR
dc.creatorRodrigo Araújo Lima Rodriguespt_BR
dc.creatorThalita Souza Arantespt_BR
dc.creatorErna Geessien Kroonpt_BR
dc.creatorCláudio Antônio Bonjardimpt_BR
dc.creatorJônatas Santos Abrahãopt_BR
dc.date.accessioned2025-02-08T00:28:16Z-
dc.date.available2025-02-08T00:28:16Z-
dc.date.issued2018-03-05-
dc.citation.volume8pt_BR
dc.citation.spage1pt_BR
dc.citation.epage11pt_BR
dc.identifier.doihttps://doi.org/10.1038/s41598-018-22398-3pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/79773-
dc.description.resumoThe giant viruses are the largest and most complex viruses in the virosphere. In the last decade, new members have constantly been added to this group. Here, we provide an in-depth descriptive analysis of the replication cycle of Cedratvirus getuliensis, one of the largest viruses known to date. We tracked the virion entry, the early steps of virus factory and particles morphogenesis, and during this phase, we observed a complex and unique sequential organization of immature particle elements, including horseshoe and rectangular compartments, revealed by transverse and longitudinal sections, respectively, until the formation of the final ovoid-shaped striped virion. The genome and virion proteins are incorporated through a longitudinal opening in the immature virion, followed by the incorporation of the second cork and thickening of the capsid well. Moreover, many cell modifications occur during viral infection, including intense membrane trafficking important to viral morphogenesis and release, as evidenced by treatment using brefeldin A. Finally, we observed that Cedratvirus getuliensis particles are released after cellular lysis, although we obtained microscopic evidence that some particles are released by exocytosis. The present study provides new information on the unexplored steps in the life cycle of cedratviruses.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofScientific Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherVírus Gigantespt_BR
dc.subject.otherViruspt_BR
dc.titleCedratvirus getuliensis replication cycle: an in-depth morphological analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.nature.com/articles/s41598-018-22398-3pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9100-0257pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9724-4164pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7926-5551pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7148-4012pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2721-3826pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9420-1791pt_BR
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