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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/80107
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Campo DCValorIdioma
dc.creatorMateus Sá Magalhães Serafimpt_BR
dc.creatorThales Kronenbergerpt_BR
dc.creatorRenata Barbosa de Oliveirapt_BR
dc.creatorErna Geessien Kroonpt_BR
dc.creatorJônatas Santos Abrahãopt_BR
dc.creatorBruno Eduardo Fernandes Motapt_BR
dc.creatorVinícius Gonçalves Maltarollopt_BR
dc.date.accessioned2025-02-14T21:16:51Z-
dc.date.available2025-02-14T21:16:51Z-
dc.date.issued2023-03-25-
dc.citation.volume3pt_BR
dc.citation.issue2pt_BR
dc.citation.spage364pt_BR
dc.citation.epage378pt_BR
dc.identifier.doihttps://doi.org/10.3390/futurepharmacol3020022pt_BR
dc.identifier.issn2673-9879pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/80107-
dc.description.resumoArboviral diseases caused by flaviviruses, such as dengue, are a continuing threat and major concern worldwide, with over three billion people estimated to be living with the risk of dengue virus (DENV) infections. There are thus far no antiviral drugs available for treatment, and limited or no vaccines are available. Curcumin and seven synthetic analogues were evaluated for their antiviral activity against dengue virus serotype 2, yellow fever virus and Zika virus, as well as for their cytotoxicity in Vero cells, both by employing MTT assays. Compounds 6 and 7, which present a thiazolylhydrazone moiety, showed moderate activity against all three flaviviruses, with selectivity index (SI) values up to 4.45. In addition, the envelope protein (E) was predicted as the potential target inhibited by both compounds, supported by molecular docking and dynamics simulation analysis. We hope that this data can contribute to the development of new curcumin antiviral analogues in the near future and can help in the search for new promising compounds as potential therapeutic agents to treat flaviviruses infections.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFuture Pharmacologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCurcumin analoguespt_BR
dc.subjectDengue virus serotype 2pt_BR
dc.subjectYellow fever viruspt_BR
dc.subjectZika viruspt_BR
dc.subject.otherVírus da Febre Amarelapt_BR
dc.subject.otherZika viruspt_BR
dc.subject.otherVírus da Denguept_BR
dc.titleSynthetic curcumin analogues present antiflavivirus activity in vitro with potential multiflavivirus activity from a thiazolylhydrazone moietypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.mdpi.com/2673-9879/3/2/22pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7505-8659pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6933-7590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0980-7375pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2721-3826pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9420-1791pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9675-5907pt_BR
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