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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/82348
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Campo DCValorIdioma
dc.creatorThaíse Oliveira Quaresmapt_BR
dc.creatorSérgio Couto Luna de Almeidapt_BR
dc.creatorTarcília Aparecida da Silvapt_BR
dc.creatorPaulo Louzada-Júniorpt_BR
dc.creatorRenê Donizeti Ribeiro de Oliveirapt_BR
dc.date.accessioned2025-05-19T20:08:32Z-
dc.date.available2025-05-19T20:08:32Z-
dc.date.issued2023-
dc.citation.volume63pt_BR
dc.citation.issue13pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1186/s42358-023-00294-3pt_BR
dc.identifier.issn2523-3106pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/82348-
dc.description.resumoIntroduction: In chronic arthropathies, there are several mechanisms of joint destruction. In recent years, studies have reported the implication of receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG) in the process of activation and differentiation of osteoclasts, a key cell in the development of bone erosion. The RANKL/OPG ratio is increased in the serum of patients with malignant diseases and lytic bone disease, as well as rheumatoid arthritis (RA). The objective of this study was to measure and compare the concentrations of OPG and RANKL in the synovial fluid (SF) of patients with rheumatoid arthritis, spondyloarthritis (SpA) and osteoarthritis (OA). Methods: This was an observational and cross-sectional study with 83 patients, 33 with RA, 32 with SpA and 18 with OA, followed up regularly in the outpatient clinics of the Rheumatology Department of the Clinics Hospital of the Ribeirão Preto Medical School-USP. All patients were assessed for indications for arthrocentesis by the attending physicians at the time of SF collection and were evaluated for demographic variables and medication use. Disease activity was assessed in individuals with RA and SpA. The quantification of SF OPG and RANKL levels was performed by ELISA, and the correlations of the results with clinical, laboratory and radiological parameters were assessed. Results: We found no statistically significant difference in the RANKL and OPG levels among the groups. Patients with RA showed a positive correlation between the SF cell count and RANKL level (r = 0.59; p < 0.05) and the RANKL/OPG ratio (r = 0.55; p < 0.05). Patients with OA showed a strong correlation between C-reactive protein (CRP) and the RANKL/OPG ratio (r = 0.82; p < 0.05). There was no correlation between the OPG and RANKL levels and markers of inflammatory activity or the disease activity index in patients with RA or SpA. Conclusion: Within this patient cohort, the RANKL/OPG ratio was correlated with the SF cell count in patients with RA and with serum CRP in patients with OA, which may suggest a relationship with active inflammation and more destructive joint disease.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentMEDICINA - FACULDADE DE MEDICINApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAdvances in rheumatologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectArthritidespt_BR
dc.subjectRheumatoid arthritispt_BR
dc.subjectSpondyloarthropathypt_BR
dc.subjectOsteoarthrosispt_BR
dc.subjectOPGL proteinpt_BR
dc.subjectRANKL proteinpt_BR
dc.subject.otherArthritispt_BR
dc.subject.otherArthritis, rheumatoidpt_BR
dc.subject.otherSpondylarthropathiespt_BR
dc.subject.otherOsteoarthritispt_BR
dc.subject.otherRANK ligandpt_BR
dc.subject.otherProteinspt_BR
dc.titleComparative study of the synovial levels of RANKL and OPG in rheumatoid arthritis, spondyloarthritis and osteoarthritispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://advancesinrheumatology.biomedcentral.com/articles/10.1186/s42358-023-00294-3pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0099-0337pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9623-7835pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2585-3870pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0229-6864pt_BR
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