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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/82460
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Campo DCValorIdioma
dc.creatorGabriela Kelly da Silvapt_BR
dc.creatorJosé Alcides Almeida de Arrudapt_BR
dc.creatorTatiana Fernandes Araújo Almeidapt_BR
dc.creatorSicília Rezende Oliveirapt_BR
dc.creatorPaula Alves da Silva Rochapt_BR
dc.creatorRicardo Alves de Mesquitapt_BR
dc.creatorZenilda de Lourdes Cardealpt_BR
dc.creatorHelvécio Costa Menezespt_BR
dc.creatorIvana Márcia Alves Dinizpt_BR
dc.creatorSoraia Macaript_BR
dc.creatorAndréia Machado Leopoldinopt_BR
dc.creatorTarcília Aparecida da Silvapt_BR
dc.date.accessioned2025-05-22T19:57:51Z-
dc.date.available2025-05-22T19:57:51Z-
dc.date.issued2023-12-
dc.citation.volume134pt_BR
dc.citation.spage104870pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.yexmp.2023.104870pt_BR
dc.identifier.issn1096-0945pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/82460-
dc.description.resumoBisphenol A (BPA) is an endocrine-disrupting chemical with a potential role in endocrine cancers. However, the effects of BPA on the salivary glands have been barely explored. We investigated the impact of in vivo sub-chronic exposure to BPA and its in vitro effects on human salivary gland mucoepidermoid carcinoma cell lines. Male and female mice were exposed to BPA (30 mg/kg/day). Sublingual and submandibular salivary glands from an estrogen-deficiency model were also analyzed. BPA concentration in salivary glands was evaluated by gas chromatography coupled to ion trap mass spectrometry. Immunohistochemical analysis using anti-p63 and anti-α-SMA antibodies was performed on mouse salivary gland tissues. Gene expression of estrogen receptors alpha and beta, P63 and α-SMA was quantified in mouse salivary gland and/or mucoepidermoid (UM-HMC-1 and UM-HMC-3A) cell lines. Cell viability, p63 and Ki-67 immunostaining were evaluated in vitro. BPA disrupted the tissue architecture of the submandibular and sublingual glands, particularly in female mice, and increased the expression of estrogen receptors and p63, effects that were accompanied by significant BPA accumulation in these tissues. Conversely, ovariectomy slightly impacted BPA-induced morphological changes. In vitro, BPA did not affect the proliferation of neoplastic cells, but augmented the expression of p63 and estrogen receptors. The present data highlight a potential harmful effect of BPA on salivary gland tissues, particularly in female mice, and salivary gland tumor cells. Our findings suggest that estrogen-dependent pathways may orchestrate the effects of BPA in salivary glands.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofExperimental and molecular pathologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBisphenol Apt_BR
dc.subjectEndocrine-disrupting chemicalpt_BR
dc.subjectEnvironmental pollutantpt_BR
dc.subjectEstrogen receptorspt_BR
dc.subjectSalivary glandspt_BR
dc.subject.otherEndocrine disruptorspt_BR
dc.subject.otherBisphenol A compoundspt_BR
dc.subject.otherEnvironmental pollutantspt_BR
dc.subject.otherReceptors, estrogenpt_BR
dc.subject.otherSalivary glandspt_BR
dc.subject.otherCarcinoma, mucoepidermoidpt_BR
dc.subject.otherSubmandibular glandpt_BR
dc.subject.otherGene expressionpt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherOvariectomypt_BR
dc.titleEffects of bisphenol A on murine salivary glands and human tumor cell linespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0014480023000217?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7643-6589pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8313-4754pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9623-7835pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6599-3950pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3216-5649pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8164-2122pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3207-4007pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3427-1864pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1383-6299pt_BR
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