1. Repositório Institucional da UFMG
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  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/82836
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Campo DCValorIdioma
dc.creatorAdriano Mota Loyolapt_BR
dc.creatorSuzana Orsini Machado Catanhede Souzapt_BR
dc.creatorJean Nunes de Souzapt_BR
dc.creatorSergio Vitorino Cardosopt_BR
dc.creatorPaulo Rogério de Fariapt_BR
dc.creatorJoão Paulo Silva Servatopt_BR
dc.creatorAna Lúcia Amaral Eisenbergpt_BR
dc.creatorFernando Luiz Diaspt_BR
dc.creatorMaria Theresa de Souza Acciolypt_BR
dc.creatorCarolina Cavalieri Gomespt_BR
dc.creatorRicardo Santiago Gomezpt_BR
dc.date.accessioned2025-06-05T20:33:12Z-
dc.date.available2025-06-05T20:33:12Z-
dc.date.issued2016-10-
dc.citation.volume69pt_BR
dc.citation.issue4pt_BR
dc.citation.spage687pt_BR
dc.citation.epage701pt_BR
dc.identifier.doihttps://doi.org/10.1111/his.12995pt_BR
dc.identifier.issn1365-2559pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/82836-
dc.description.resumoAims: Ameloblastic carcinoma (AMECA) is an odontogenic malignancy that combines the histological features of ameloblastoma and cytological atypia. Because of its rarity, it poses difficulties in diagnosis. The aim of this study was to investigate the socio-demographic data, histopathology, immunohistochemical features, treatment and outcomes of 17 cases. Methods and results: Descriptive statistical analyses were used to portray the clinicopathological data collected, retrospectively. Log-rank tests were performed to determine new prognostic factors. Lesions were immunostained for Ki67, p16, p53, and cytokeratins (CKs), and compared with solid/multicystic ameloblastomas (n = 15). AMECA was mostly diagnosed at a late stage, affecting the posterior mandible of male patients in their fifth decade of life. Recurrence was diagnosed in nearly 90% of treated patients, and metastasis occurred in four patients. The mean number of Ki67-positive cells was 86.4 ± 66 per field. Tumours were focally positive for CK7, CK8, CK14, and CK18, and diffusely positive for CK19, p53, and p16. AMECA showed increased immunoexpression of CK18, CK19, p16, p53 and Ki67 as compared with benign cases. Conclusions: Our study has contributed to the improved characterization of the epidemiology, prognostic markers, treatment options and outcomes of AMECA. Current criteria must be reviewed to simplify the diagnostic process for these neoplasms.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofHistopathology (Oxford)pt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectAmeloblastomapt_BR
dc.subjectCarcinomapt_BR
dc.subjectEpidemiologypt_BR
dc.subjectOdontogenic tumorspt_BR
dc.subjectPathologypt_BR
dc.subject.otherAmeloblastomapt_BR
dc.subject.otherCarcinomapt_BR
dc.subject.otherEpidemiologypt_BR
dc.subject.otherOdontogenic Tumorspt_BR
dc.subject.otherPathologypt_BR
dc.subject.otherKeratinspt_BR
dc.subject.otherKi-67 antigenpt_BR
dc.subject.otherCell countpt_BR
dc.subject.otherProteinspt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherHistologypt_BR
dc.subject.otherPrognosispt_BR
dc.subject.otherTherapeuticspt_BR
dc.subject.otherMandiblept_BR
dc.subject.otherRecurrencept_BR
dc.subject.otherNeoplasm metastasispt_BR
dc.subject.otherDiagnosispt_BR
dc.titleAmeloblastic carcinoma: a brazilian collaborative study of 17 casespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/his.12995pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9707-9365pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1809-0617pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2650-3960pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1783-8777pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0170-1170pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1000-7436pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1423-0398pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1580-4995pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8770-8009pt_BR
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