1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Evento
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/82900
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorSílvia Ferreira de Sousapt_BR
dc.creatorRennan Garcias Moreirapt_BR
dc.creatorRicardo Santiago Gomezpt_BR
dc.creatorCarolina Cavaliéri Gomespt_BR
dc.date.accessioned2025-06-11T20:49:35Z-
dc.date.available2025-06-11T20:49:35Z-
dc.date.issued2017-08-
dc.citation.volume124pt_BR
dc.citation.issue2pt_BR
dc.citation.spagee139pt_BR
dc.citation.epagee139pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2017.05.393pt_BR
dc.identifier.issn2212-4411pt_BR
dc.identifier.sici2pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/82900-
dc.description.resumoTo simultaneously interrogate in calcifying cystic odonto genic tumor (CCOT) about 2,800 COSMIC mutations in a panel of important oncogenes and tumor suppressor genes. Study Design: 3 samples of CCOT were analyzed. It was used the Ion AmpliSeq Cancer Hotspot Panel v2 to interrogate mutations at 50 tumor suppressor genes and oncogenes by target next generation sequencing on the Ion Personal Genome Machine (PGM) System. Reads were aligned to genome (hg19), variants were called using Ion Reporter Software and false variants were excluded after assessment at the Integrative Genomics Viewer (IGV). Results: The only pathogenic mutation detected in 2 out of 3 CCOT was in b-Catenin gene, CTNNB1 c.98C>T. This mutation leads to substitution from serine to phenylalanine at codon 33 of b-Catenin, resulting in its stabilization and oncogenic activation. No other pathogenic mutation interrogated was detected, including the recurrent mutations BRAFV600E, recently described in ameloblastomas or KRASG12V, recently described in adenomatoid odontogenic tumors. Conclusion: b-Catenin gene mutation persists as the pivotal alteration reported in CCOTs. This study gives further support to the concept that odontogenic tumors do not share a common genetic event and each tumor type shows a specific molecular profile.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral surgery, Oral medicine, Oral Pathology and Oral Radiologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherMutationpt_BR
dc.subject.otherGenespt_BR
dc.subject.otherOdontogenic tumorspt_BR
dc.subject.otherOdontogenic cyst, calcifyingpt_BR
dc.subject.otherCarcinogenesispt_BR
dc.titleInterrogation of cancer hotspot mutations in calcifying cystic odontogenic tumorpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.oooojournal.net/article/S2212-4403(17)30692-2/fulltextpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7820-4749pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2775-1333pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8770-8009pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1580-4995pt_BR
Aparece en las colecciones:Artigo de Evento

archivos asociados a este elemento:
no existem archivos asociados a este elemento.
Mostrar registro simple del elemento Visualizar estadísticas


Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.