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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/82956
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Campo DCValorIdioma
dc.creatorHelvécio Marangon Juniorpt_BR
dc.creatorPriscila Laiza Rubim Leãopt_BR
dc.creatorVictória Vasconcellos Moreira Melopt_BR
dc.creatorÂngela Braga Caixetapt_BR
dc.creatorPaulo Eduardo Alencar Souzapt_BR
dc.creatorMaria Cassia Ferreira de Aguiarpt_BR
dc.creatorMartinho Campolina Rebello Hortapt_BR
dc.date.accessioned2025-06-13T19:56:58Z-
dc.date.available2025-06-13T19:56:58Z-
dc.date.issued2018-02-
dc.citation.volume47pt_BR
dc.citation.issue2pt_BR
dc.citation.spage128pt_BR
dc.citation.epage135pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.12653pt_BR
dc.identifier.issn1600-0714pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/82956-
dc.description.resumoBackground: Tumor budding is a morphological marker of cancer invasion, defined as the presence of isolated or small clusters of neoplastic cells at the tumor invasive front. This study aimed to evaluate the association between intensity of tumor budding and cell proliferation in oral squamous cell carcinoma (OSCC). Methods: Immunohistochemistry was employed in 163 OSCC samples to detect the cell proliferation marker Ki-67 and multicytokeratin (to identify OSCC cells in tumor budding evaluation). The Mann-Whitney test was used to evaluate differences in the cell proliferation index between samples with high-intensity tumor budding and samples with low-intensity or no tumor budding. In samples with high-intensity tumor budding, the Wilcoxon test was used to evaluate differences in the cell proliferation index between the budding area and the area outside the budding. The chi-square test assessed the association between cell proliferation index and intensity of tumor budding. Results: The cell proliferation index was higher in samples with high-intensity tumor budding than in samples with low-intensity or no tumor budding (P < .05). Tumors with high-intensity tumor budding showed a higher cell proliferation index in the budding area than in the area outside the budding (P < .05). Finally, samples showing high-intensity tumor budding were associated with high cell proliferation index (P < .05). Conclusion: Cell proliferation is positively associated with intensity of tumor budding in OSCC. Moreover, in tumors showing high-intensity tumor budding, the budding area is the location of higher cell proliferation. These findings reinforce the hypothesis that tumor budding is associated with the biological behavior of OSCC.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology & Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectCell proliferationpt_BR
dc.subjectOral cancerpt_BR
dc.subjectOral squamous cell carcinomapt_BR
dc.subjectTumor buddingpt_BR
dc.subject.otherCell proliferationpt_BR
dc.subject.otherMouth neoplasmspt_BR
dc.subject.otherSquamous cell carcinoma of head and neckpt_BR
dc.subject.otherEvaluation studypt_BR
dc.subject.otherAssociationpt_BR
dc.titleCell proliferation is associated with intensity of tumor budding in oral squamous cell carcinomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12653pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9709-6795pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0876-0568pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5166-1982pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5134-3466pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0192-5614pt_BR
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