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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/83114
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Campo DCValorIdioma
dc.creatorMariana Passos de Lucapt_BR
dc.creatorIrlan Almeida Freirespt_BR
dc.creatorAlfonso Gala Garciapt_BR
dc.creatorVagner Rodrigues Santospt_BR
dc.creatorMiriam Parreira Pimenta do Valept_BR
dc.creatorSeverino Matias de Alencarpt_BR
dc.creatorPedro Luiz Rosalenpt_BR
dc.date.accessioned2025-06-24T21:47:23Z-
dc.date.available2025-06-24T21:47:23Z-
dc.date.issued2017-
dc.citation.volume31pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1590/1807-3107BOR-2017.vol31.0045pt_BR
dc.identifier.issn1807-3107pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/83114-
dc.description.resumoWe investigated the anti-caries effects of an experimental propolis varnish in vivo, and further tested its toxicity against fibroblasts. Fifty-six SPF female Wistar rats were infected with Streptococcus mutans UA159 (SM) and allocated into four groups (n = 14/group): G1, propolis varnish (15%/PV); G2, chitosan varnish (CV/vehicle); G3, gold standard (GS/Duraphat®); and G4, untreated. The animals received a single varnish application on their molars and were submitted to a high cariogenic challenge (Diet-2000, 56% sucrose, and 5% sucrose-added water, ad libitum) for 4 weeks. Total cultivable microbiota and SM were counted, and smooth-surface and sulcal caries were scored. PV, CV and GS cytotoxic effects were tested against fibroblasts. The data were analyzed using ANOVA with the Tukey-Kramer test (p ≤ 0.05). Total microbiota and SM counts did not differ among the treatments (p = 0.78), or in relation to the untreated group (p = 0.52). PV reduced development of smooth-surface enamel caries compared with the untreated group (p = 0.0018), with no significant difference from GS (p = 0.92); however, the PV effects were no longer observed when the dentin was affected. Neither PV nor GS prevented enamel sulcal lesion onset, but GS significantly reduced the severity of dentinal sulcal lesions (p < 0.0001). No significant difference was observed in fibroblast viability between PV and GS (p < 0.0001). In conclusion, PV prevented smooth-surface enamel caries and showed low cell toxicity. Nevertheless, due to the high cariogenic challenge, its effects were not sustained throughout the experiment. Further studies are encouraged to establish a protocol to sustain the long-term anti-caries activity of PV in the oral cavity.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Oral Researchpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPropolispt_BR
dc.subjectStreptococcus mutanspt_BR
dc.subjectDental cariespt_BR
dc.subjectModelspt_BR
dc.subjectAnimalpt_BR
dc.subject.otherPropolispt_BR
dc.subject.otherStreptococcus mutanspt_BR
dc.subject.otherDental cariespt_BR
dc.subject.otherModels animalpt_BR
dc.subject.otherFibroblastspt_BR
dc.subject.otherPharmacological and toxicological phenomenapt_BR
dc.subject.otherDental enamelpt_BR
dc.subject.otherDentinpt_BR
dc.titleThe anti-caries activity and toxicity of an experimental propolis-containing varnishpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bor/a/WTgHPPrK3kTwkv6VwCkwjMM/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7995-4218pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1079-6941pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3934-1094pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5370-4867pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8781-778Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6637-7973pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0812-4027pt_BR
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