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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/83317
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Campo DCValorIdioma
dc.creatorAline Fernanda Cruzpt_BR
dc.creatorRenata Gonçalves de Resendept_BR
dc.creatorJúlio César Tanos de Lacerdapt_BR
dc.creatorNubia Braga Pereirapt_BR
dc.creatorLeonardo Augusto de Melopt_BR
dc.creatorMarina Gonçalves Dinizpt_BR
dc.creatorCarolina Cavalieri Gomespt_BR
dc.creatorRicardo Santiago Gomezpt_BR
dc.date.accessioned2025-07-03T19:05:17Z-
dc.date.available2025-07-03T19:05:17Z-
dc.date.issued2018-01-
dc.citation.volume47pt_BR
dc.citation.issue1pt_BR
dc.citation.spage91pt_BR
dc.citation.epage95pt_BR
dc.identifier.doihttps://doi.org/10.1111/jop.12645pt_BR
dc.identifier.issn1600-0714pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/83317-
dc.description.resumoBackground: The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune-mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response-related genes in the different clinical forms of oral lichen planus. Methods: A cross-sectional study was performed to analyse the DNA methylation patterns in three distinct groups of oral lichen planus: (i) reticular/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After DNA extraction from biopsies, the samples were submitted to digestions by methylation-sensitive and methylation-dependent enzymes and double digestion. The relative percentage of methylated DNA for each gene was provided using real-time polymerase chain reaction arrays. Results: Hypermethylation of the STAT5A gene was observed only in the control group (59.0%). A higher hypermethylation of the ELANE gene was found in reticular/plaque lesions (72.1%) compared to the erosive lesions (50.0%). Conclusion: Our results show variations in the methylation profile of immune response-related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology & Medicinept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectEpigeneticpt_BR
dc.subjectInflammationpt_BR
dc.subjectLichen planuspt_BR
dc.subjectMethylationpt_BR
dc.subjectOral lichen planuspt_BR
dc.subject.otherEpigenomicspt_BR
dc.subject.otherInflammationpt_BR
dc.subject.otherLichen planuspt_BR
dc.subject.otherMethylationpt_BR
dc.subject.otherLichen planus, oralpt_BR
dc.subject.otherGenespt_BR
dc.subject.otherDental plaquept_BR
dc.subject.otherTooth erosionpt_BR
dc.subject.otherImmunitypt_BR
dc.titleDNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planuspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12645pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5570-3550pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6714-3124pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3081-7778pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4212-1172pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1580-4995pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8770-8009pt_BR
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