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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/83326
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Campo DCValorIdioma
dc.creatorFernando Antônio Castrocarvalhopt_BR
dc.creatorRodrigo Otávio Silveira Silvapt_BR
dc.creatorBárbara Moreira Ribeiro Trindade Dos Santospt_BR
dc.creatorAmanda Nádia Dinizpt_BR
dc.creatorEduardo Garcia Vilelapt_BR
dc.date.accessioned2025-07-03T22:15:52Z-
dc.date.available2025-07-03T22:15:52Z-
dc.date.issued2023-
dc.citation.volume60pt_BR
dc.citation.issue3pt_BR
dc.citation.spage330pt_BR
dc.citation.epage338pt_BR
dc.identifier.doihttps://doi.org/10.1590/S0004-2803.230302023-36pt_BR
dc.identifier.issn16784219pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/83326-
dc.description.resumoABSTRACT – Background – Clostridioides difficile infection (CDI) is a potentially severe disease that can present with refractoriness, recurrence, and evolution to death. In Brazil, the epidemiology of CDI seems to differ from that of the United States and most European countries, with only one ribotype (RT) 027-related case and a high prevalence of RT106. Objective – The aim of this study was to evaluate the outcomes of CDI and its possible association with ribotypes at a university hospital in Brazil. Methods – A total of 65 patients with CDI were included and stool samples were submitted to A/B toxin detection and toxigenic culture, and toxigenic isolates (n=44) were also PCR ribotyped. Results – Patients’ median age was 59 (20–87) years and there were 16 (24.6%) deaths. The median Charlson comorbidity index (CCI) was 4 (0–15) and 16.9% of the patients had CCI ≥8. The ATLAS score and non-improvement of diarrhea were related to higher mortality. A longer length of hospitalization was related to the enteral nutrition and use of multiple antibiotics. The period between CDI diagnosis and hospital discharge was longer in those who received new antibiotics after diagnosis, multiple antibiotics, and required intensive care treatment. Recurrence was associated with CCI >7. Twenty ribotypes were identified and RT106 was the most frequently detected strain (43.2%). No relationship was observed between the ribotypes and outcomes. CDI was present in patients with more comorbidities. Conclusion – Risk factors for higher mortality, longer hospital stay and recurrence were identified. A diversity of ribotypes was observed and C. difficile strains were not related to the outcomes.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentVET - DEPARTAMENTO DE MEDICINA VETERINÁRIA PREVENTIVApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArquivos de Gastroenterologiapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPseudomembranous colitispt_BR
dc.subjectantibiotic associated diarrheapt_BR
dc.subjectAtlaspt_BR
dc.subject.otherEnterocolitis, Pseudomembranouspt_BR
dc.subject.otherAtlaspt_BR
dc.titleClinical outcome and severity of clostridioides (clostridium) difficile infection at a tertiary referral hospital in brazilpt_BR
dc.title.alternativeDesfechos clínicos e gravidade da infecção pelo Clostridioides (Clostridium) difficile em um hospital terciário de referência no Brasilpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/ag/a/yDhgVjLkCSVXdYqvYmjrcVK/?format=pdf&lang=enpt_BR
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