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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/83786
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Campo DCValorIdioma
dc.creatorLara Jhullian Tolentinovieirapt_BR
dc.creatorLilian Martins Oliveira Dinizpt_BR
dc.creatorGabriela Assunção Goebelpt_BR
dc.creatorYuri Barcelospt_BR
dc.creatorLuciana Oliveira Cunhapt_BR
dc.creatorLuisa Teles Melo Santospt_BR
dc.creatorRoberta Maia de Castro Romanellipt_BR
dc.creatorFernanda Gontijo Minafrapt_BR
dc.creatorAndrea Lucchesi de Carvalhopt_BR
dc.creatorLuiz Fernando Andrade de Carvalhopt_BR
dc.date.accessioned2025-07-23T20:22:03Z-
dc.date.available2025-07-23T20:22:03Z-
dc.date.issued2024-
dc.citation.volume66pt_BR
dc.citation.issuee50pt_BR
dc.citation.spage1pt_BR
dc.citation.epage5pt_BR
dc.identifier.doihttps://doi.org/10.1590/S1678-9946202466050pt_BR
dc.identifier.issn16789946pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/83786-
dc.description.resumoYellow fever vaccine (YFV) is a live attenuated vaccine that can cause a mild infection in immunocompetent patients. However, it may not be self-limiting in patients with inborn errors of immunity (IEI) and may be the first and most severe presentation in these patients. A 10-month-old female infant sought emergency care presenting fever for three days and diffuse exanthema. She was a previous healthy child of consanguineous parents. The child had received YFV 28 days before the onset of symptoms. Upon hospital admission, petechial rash on the limbs and hepatosplenomegaly were noted on physical exam. Laboratory tests showed thrombocytopenia, increased serum aminotransferases and elevated gamma-glutamyl transferase (GGT) and alkaline phosphatase levels. During hospitalization she developed hypoactivity, drowsiness, and hypotonia. The possibility of viscerotropic and neurotropic vaccine associated disease was suspected and a possible primary immunodeficiency disease considered. The patient was tested for antibodies against the yellow fever virus (MAC ELISA) on serum and cerebrospinal fluid (CSF) samples, showing positive IgM results. Immunophenotyping showed low levels of lymphocytes and absence of T-cell receptor excision circles (TREC), leading to diagnose of severe combined immunodeficiency disease (SCID). Despite treatment, after 35 days of hospitalization, she evolved to cardiorespiratory arrest and death. Serious adverse events after administration of the YFV are rare and associated with neurological or visceral involvement in most cases. The unfavorable outcome highlights the importance of neonatal screening for SCID and the clinical suspicion of primary immunodeficiencies in infants who have serious adverse events to live virus vaccines.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulopt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectVaccine.pt_BR
dc.subjectImmunodeficiencypt_BR
dc.subjectYellow Feverpt_BR
dc.subject.otherYellow Feverpt_BR
dc.subject.otherVaccinept_BR
dc.titleFatal viscerotropic and neurotropic disease after yellow fever vaccine: a rare manifestation leading to diagnosis of severe combined immunodeficiency in an infantpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/rimtsp/a/hQhChbDC7sJPNvDMzqhxVZd/?lang=enpt_BR
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