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  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/84216
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Campo DCValorIdioma
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorOslei Paes de Almeidapt_BR
dc.creatorAlan Roger Santos-Silvapt_BR
dc.creatorMárcio Ajudarte Lopespt_BR
dc.creatorPablo Agustin Vargaspt_BR
dc.creatorCarolina Carneiro Soares Macedopt_BR
dc.creatorSara Ferreira Dos Santos Costapt_BR
dc.creatorAdriana Franco Paes Lemept_BR
dc.creatorRomênia Ramos Rodriguespt_BR
dc.creatorHélder Antônio Rebelo Pontespt_BR
dc.creatorAlbina Altemanipt_BR
dc.creatorWillie F.P. van Heerdenpt_BR
dc.creatorManoela Domingues Martinspt_BR
dc.date.accessioned2025-08-08T19:03:00Z-
dc.date.available2025-08-08T19:03:00Z-
dc.date.issued2019-12-
dc.citation.volume128pt_BR
dc.citation.issue6pt_BR
dc.citation.spage639pt_BR
dc.citation.epage650pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2019.07.016pt_BR
dc.identifier.issn2212-4411pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/84216-
dc.description.resumoObjective: The aim of this study was to determine the proteome of adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAc) and to identify a protein signature useful in distinguishing these two neoplasms. Study design: Ten cases of AdCC and 10 cases of PAc were microdissected for enrichment of neoplastic tissue. The samples were submitted to liquid chromatography-tandem mass spectrometry (LC-MS/MS), and the proteomics data were analyzed by using the MaxQuant software. LC-MS/MS spectra were searched against the Human UniProt database, and statistical analyses were performed with Perseus software. Bioinformatic analyses were performed by using discovery-based proteomic data on both tumors. Results: LC-MS/MS analysis identified 1957 proteins. The tumors shared 1590 proteins, and 261 were exclusively identified in AdCC and 106 in PAc. Clustering analysis of the statistically significant proteins clearly separated AdCC from PAc. Protein expression 10 times higher in one group than in the other led to a signature of 16 proteins-6 upregulated in AdCC and 10 in PAc. A new clustering analysis showed reverse regulation and also differentiated both tumors. Conclusions: Global proteomics may be useful in discriminating these two malignant salivary neoplasms that frequently show clinical and microscopic overlaps, but additional validation studies are still necessary to determine the diagnostic potential of the protein signature obtained.pt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Surgery Oral Medicine oral Pathology Oral Radiologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherProteomept_BR
dc.subject.otherProteinspt_BR
dc.subject.otherSalivary gland neoplasmspt_BR
dc.subject.otherDiagnosispt_BR
dc.subject.otherCarcinoma, adenoid cysticpt_BR
dc.subject.otherAdenocarcinomapt_BR
dc.titleMass spectrometry-based proteome profile may be useful to differentiate adenoid cystic carcinoma from polymorphous adenocarcinoma of salivary glandspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2212440319313719?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2494-667Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6657-4547pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2002-8003pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2040-6617pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6677-0065pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1840-4911pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9858-8206pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5150-9227pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7609-8804pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9944-9734pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8662-5965pt_BR
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