Aspergilose em pacientes submetidos a transplantes

Abstract

In the last years there is been an exponential growth in the number of transplant. The great problem is the rejection, which can occur by cellular and/or humoral response. The use of immunosuppressive drugs aims to control this matter. Thereby, the patients who have been through transplant are a significant group of immunocompromised people and they are more susceptible to be infected by species of Aspergillus. Infections by Aspergillus occur in 2 to 26% of patients thathave been through bone marrow transplant and in 1 to 15% of patients that received any solid organ. The mortality rate in transplanted people caused by invasive aspergillosis varies between 74 and 92% and it is estimated that 9.3 to 16.9% of all deaths in the first year after the transplant are due to invasive aspergillosis. Due to the epidemiological relevance of aspergillosis in transplant patients and mostly to thehigh mortality rate of this disease and also the increasing number of Aspergillus that are resistant to the available drugs, it is necessary an updated research about the aspergillosis pathophysiology in order to highlight the major points to develop actions that would avoid the emergence of new cases and to point out the best diagnosticmethods and treatments