Estudo longitudinal da dosagem urinária da Endoglina e da Creatinina como preditores da Preeclâmpsia

Abstract

The preeclampsia (PE) is a specific disease of pregnancy and a major cause of maternal and perinatal mortality and morbidity in the world. The etiology is still obscure and placental, and vascular mechanisms related to this disorder remain unclear. During the last decades, several studies of clinical, biophysical and biochemical screening seek early and effective markers of preeclampsia that would be accessible and useful even through the prenatal. The objective of this work was to check and examine the urinary dosages of endoglin and creatinine as predictors of PE in pregnancies with risk factors. This longitudinal study included 87 pregnant women enrolled during their prenatal routine consultation at the Pregnancy Ambulatory Jenny Faria, placed in the Hospital of the Federal University of Minas Gerais. Longitudinal samples of urine were collected, scheduled for before and after 20 weeks of pregnancy. Urinary concentration of creatinine was determinated by the kinetic colorimetric method, and readings were obtained in absorbance with a correction factor. Urinary concentration of endoglin was performed by ELISA technique. The comparative and individual rates of urinary concentration of endoglin was not significant (p> 0.05), both before and after 20 weeks, among women with PE and normotensives. We evaluated the predictive capacity of the urinary concentration of creatinine found in the two study groups. For each 1mg / dL in the concentration of urinary creatinine sample obtained before 20 weeks of pregnancy, the chance of developing PE increases 1.5% (p = 0.001). The urinary concentrations of endoglin, measured before and after 20 weeks of pregnancy in random samples of pregnant women with risk factors for PE, were not associated with disease in delivery. However, a greater chance of developing PE was associated with a urinary creatinine concentration in a random sample, collected during the first half of pregnancy.