Oral kefir grains supplementation improves metabolism and liver antioxidant enzymes expression in malnourished mice

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dc.creatorFábio Ribeiro Santos
dc.creatorAmanda Souto Machado
dc.creatorDeborah Farias Lelis
dc.creatorAndré Luiz Sena Guimarães
dc.creatorAlfredo Maurício Batista de Paula
dc.creatorRenato Sobral Monteiro Júnior
dc.creatorTheles de Oliveira Costa
dc.creatorIgor Viana Brandi
dc.creatorJúnio Cota Silva
dc.creatorSergio Henrique Sousa Santos
dc.date.accessioned2022-08-31T14:22:56Z
dc.date.accessioned2025-09-09T00:58:55Z
dc.date.available2022-08-31T14:22:56Z
dc.date.issued2020-11-24
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.identifier.issn2381-8980
dc.identifier.urihttps://hdl.handle.net/1843/44766
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofAustin Journal of Nutrition and Food Sciences
dc.rightsAcesso Aberto
dc.subjectDieta de baixa caloria
dc.subjectDesnutrição
dc.subjectStress oxidativo
dc.subjectKefir
dc.titleOral kefir grains supplementation improves metabolism and liver antioxidant enzymes expression in malnourished mice
dc.typeArtigo de periódico
local.citation.issue3
local.citation.spage1148
local.citation.volume8
local.description.resumoScope: this study has a novel approach to investigate the effects of oral supplementation of kefir grains on metabolic improvement and the expression of the antioxidant enzymes Glutathione Peroxidase (GPx) and Catalase (CAT) of the liver in malnourished mice. Method and results: swiss mice were divided into four groups and subjected to two treatment phases: the food restriction phase of 20% in relation to the control group was maintained until animals reached a weight deficit of about 20% in relation to their original weight and the renutrition phase, the animals received diets every day for 30 days. Diets (chow powder plus kefir grains) were administered orally. Thereafter, during throughout the experiment measurements of body weight and energy consumption were obtained. After the end of treatment, fasting glucose tolerance tests were performed at night and insulin sensitivity with fed mice. Soon in then, the mice were euthanized by beheading in guillotine and the blood and liver were collected for evaluation of biochemical parameters, Histopathological assessments and Reverse transcriptase (RT-PCR). Conclusion: the present study demonstrated the kefir grains ability to modulate inflammation and hepatic oxidative-stress under malnourished-state.
local.publisher.countryBrasil
local.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
local.publisher.initialsUFMG
local.url.externahttps://austinpublishinggroup.com/nutrition-food-sciences/fulltext/ajnfs-v8-id1148.pdf

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